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    tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) [ Danio rerio (zebrafish) ]

    Gene ID: 494033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tfap2cprovided by ZNC
    Official Full Name
    transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-61
    See related
    Ensembl:ENSDARG00000040606 AllianceGenome:ZFIN:ZDB-GENE-041212-61
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb48g05; fb49c04; zgc:92088; wu:fb48g05; wu:fb49c04
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within neural crest cell differentiation; olfactory placode development; and otic placode formation. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; epidermis; eye; neurogenic field; and presumptive ectoderm. Orthologous to human TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tfap2c in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (56141839..56179707)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (56157640..56195515)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene uncharacterized LOC137496030 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7 Neighboring gene uncharacterized LOC137496031 Neighboring gene uncharacterized LOC137495896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the new vertebrate head by co-option of an ancient chordate skeletal tissue. Jandzik D, et al. Nature, 2015 Feb 26. PMID 25487155
    2. TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes. Kenny C, et al. PLoS Genet, 2022 May. PMID 35580127, Free PMC Article
    3. Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development. Manohar M, et al. Biochemistry, 2010 Aug 10. PMID 20578725
    4. Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. Hoffman TL, et al. J Exp Zool B Mol Dev Evol, 2007 Sep 15. PMID 17724731
    5. Effects of ethinylestradiol and of an environmentally relevant mixture of xenoestrogens on steroidogenic gene expression and specific transcription factors in zebrafish. Urbatzka R, et al. Environ Pollut, 2012 May. PMID 22318008

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ectodermal placode development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ectodermal placode formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory placode development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otic placode formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor AP-2 gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008576.2 → NP_001008576.1  transcription factor AP-2 gamma

      See identical proteins and their annotated locations for NP_001008576.1

      Status: VALIDATED

      Source sequence(s)
      CU468952
      UniProtKB/TrEMBL
      A0A8M1N383, Q5PQZ4
      Related
      ENSDARP00000123798.1, ENSDART00000150219.2
      Conserved Domains (1) summary
      pfam03299
      Location:215 → 415
      TF_AP-2; Transcription factor AP-2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      56141839..56179707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356481.3 → XP_017211970.1  transcription factor AP-2 gamma isoform X2

      UniProtKB/TrEMBL
      A0A8M6YYQ6

    2. XM_021476853.2 → XP_021332528.1  transcription factor AP-2 gamma isoform X3

      UniProtKB/TrEMBL
      A0A8M9PZP3
      Conserved Domains (1) summary
      pfam03299
      Location:210 → 404
      TF_AP-2; Transcription factor AP-2

    3. XM_021476852.2 → XP_021332527.1  transcription factor AP-2 gamma isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM23
      Conserved Domains (1) summary
      pfam03299
      Location:216 → 410
      TF_AP-2; Transcription factor AP-2
    Nucleotide Protein
    Heading Accession and Version

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