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    saraf store-operated calcium entry-associated regulatory factor [ Danio rerio (zebrafish) ]

    Gene ID: 767649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sarafprovided by ZNC
    Official Full Name
    store-operated calcium entry-associated regulatory factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-208
    See related
    Ensembl:ENSDARG00000070452 AllianceGenome:ZFIN:ZDB-GENE-060929-208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmem66; zgc:153286
    Summary
    Predicted to be involved in regulation of store-operated calcium entry. Predicted to act upstream of or within calcium ion transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See saraf in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12049255..12058626)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11362434..11371826)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 2 Neighboring gene uncharacterized LOC137495449 Neighboring gene phospholipase A2, group XIIA Neighboring gene uncharacterized LOC110439783

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153286

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of store-operated calcium entry IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    store-operated calcium entry-associated regulatory factor
    Names
    SOCE-associated regulatory factor
    transmembrane protein 66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076589.1 → NP_001070057.1  store-operated calcium entry-associated regulatory factor precursor

      See identical proteins and their annotated locations for NP_001070057.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124302
      UniProtKB/Swiss-Prot
      E9QGQ1, F1QPC3, Q08CB8
      Related
      ENSDARP00000094179.3, ENSDART00000103403.5
      Conserved Domains (1) summary
      pfam06682
      Location:17 → 345
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      12049255..12058626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159818.5 → XP_005159875.1  store-operated calcium entry-associated regulatory factor isoform X1

      UniProtKB/Swiss-Prot
      E9QGQ1, F1QPC3, Q08CB8
      UniProtKB/TrEMBL
      A0A8M2B6M4, J9PBQ1
      Related
      ENSDARP00000115385.1, ENSDART00000137697.2
      Conserved Domains (1) summary
      pfam06682
      Location:17 → 346
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QPC3.1 GenPept UniProtKB/Swiss-Prot:F1QPC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.