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    fdft1 farnesyl-diphosphate farnesyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 571911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fdft1provided by ZNC
    Official Full Name
    farnesyl-diphosphate farnesyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-242
    See related
    Ensembl:ENSDARG00000101062 AllianceGenome:ZFIN:ZDB-GENE-081104-242
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-107c13.2
    Summary
    Predicted to enable squalene synthase [NAD(P)H] activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fdft1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (52904404..52939329, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (53101980..53133912, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene desmoplakin b Neighboring gene cathepsin Bb Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC137488707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of Phenanthrene Exposure on Cholesterol Homeostasis and Cardiotoxicity in Zebrafish Embryos. McGruer V, et al. Environ Toxicol Chem, 2021 Jun. PMID 33523501
    2. 0# Diesel water-accommodated fraction induced lipid homeostasis alteration in zebrafish embryos. Mu X, et al. Environ Pollut, 2018 Nov. PMID 30373040
    3. Myclobutanil developmental toxicity, bioconcentration and sex specific response in cholesterol in zebrafish (Denio rerio). Pang S, et al. Chemosphere, 2020 Mar. PMID 31677519
    4. AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Deng R, et al. Acta Neuropathol, 2023 Aug. PMID 37119330, Free PMC Article
    5. Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Mu X, et al. Environ Pollut, 2015 Feb. PMID 25483594

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables farnesyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene synthase [NAD(P)H] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    squalene synthase
    Names
    squalene synthetase
    NP_001189454.1
    XP_021324186.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202525.1 → NP_001189454.1  squalene synthase

      Status: PROVISIONAL

      Source sequence(s)
      CU207296
      UniProtKB/TrEMBL
      A0A0R4IVV5, A0A8M1P1T1
      Related
      ENSDARP00000141194.1, ENSDART00000166508.2
      Conserved Domains (1) summary
      cl00210
      Location:40 → 368
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      52904404..52939329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468511.2 → XP_021324186.1  squalene synthase isoform X1

      UniProtKB/TrEMBL
      A0A8M9PPK1
      Conserved Domains (1) summary
      cl00210
      Location:69 → 397
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    Nucleotide Protein
    Heading Accession and Version

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