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    kcnb2a potassium voltage-gated channel subfamily B member 2a [ Danio rerio (zebrafish) ]

    Gene ID: 555921, updated on 9-Dec-2024

    Summary

    Official Symbol
    kcnb2aprovided by ZNC
    Official Full Name
    potassium voltage-gated channel subfamily B member 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-170
    See related
    Ensembl:ENSDARG00000038862 AllianceGenome:ZFIN:ZDB-GENE-070912-170
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    kcnb2; si:ch211-193n21.1
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport; potassium ion transport; and protein homooligomerization. Predicted to be located in perikaryon. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendrite; membrane; and neuronal cell body. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See kcnb2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30144979..30176543)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30161190..30193938)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene sonic hedgehog signaling molecule b Neighboring gene DnaJ heat shock protein family (Hsp40) member B6a Neighboring gene transient receptor potential cation channel, subfamily A, member 1a Neighboring gene small nucleolar SNORD12/SNORD106 Neighboring gene ribosomal protein L7 Neighboring gene retinol dehydrogenase 10b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel subfamily B member 2a
    Names
    potassium voltage-gated channel, Shab-related subfamily, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      30144979..30176543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163446.5XP_005163503.1  potassium voltage-gated channel subfamily B member 2

      See identical proteins and their annotated locations for XP_005163503.1

      UniProtKB/TrEMBL
      A0A8M2BAM8, B0V2U3
      Related
      ENSDARP00000107363.2, ENSDART00000129365.3
      Conserved Domains (5) summary
      smart00225
      Location:36142
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:229427
      Ion_trans; Ion transport protein
      pfam02214
      Location:36135
      BTB_2; BTB/POZ domain
      pfam03521
      Location:473695
      Kv2channel; Kv2 voltage-gated K+ channel
      pfam07885
      Location:340421
      Ion_trans_2; Ion channel
    2. XM_678581.10XP_683673.2  potassium voltage-gated channel subfamily B member 2

      See identical proteins and their annotated locations for XP_683673.2

      UniProtKB/TrEMBL
      A0A8M2BAM8, B0V2U3
      Conserved Domains (5) summary
      smart00225
      Location:36142
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:229427
      Ion_trans; Ion transport protein
      pfam02214
      Location:36135
      BTB_2; BTB/POZ domain
      pfam03521
      Location:473695
      Kv2channel; Kv2 voltage-gated K+ channel
      pfam07885
      Location:340421
      Ion_trans_2; Ion channel