mta3 metastasis associated 1 family, member 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mta3provided by ZNC
Official Full Name: metastasis associated 1 family, member 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6485
See related: Ensembl:ENSDARG00000054903 AllianceGenome:ZFIN:ZDB-GENE-030131-6485
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mta1; fj99h01; zgc:56396; wu:fj99h01
Summary: Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within primitive hemopoiesis. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Predicted to be active in nucleoplasm. Is expressed in blastodisc; central nervous system; and intermediate cell mass of mesoderm. Orthologous to human MTA3 (metastasis associated 1 family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (25223843..25288722)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (25132483..25175769)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that Mta3-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
Title: Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fj99h01.x1 (e-PCR)
- UniSTS:200484

fe48a11.y1 (e-PCR)
- UniSTS:196506

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primitive hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: metastasis-associated protein MTA3

Names: metastasis associated family, member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199912.2 → NP_956206.1 metastasis-associated protein MTA3

See identical proteins and their annotated locations for NP_956206.1

Status: PROVISIONAL

Source sequence(s)

BC049310

UniProtKB/TrEMBL

Q7ZUE1

Related

ENSDARP00000071648.5, ENSDART00000077180.7

Conserved Domains (6) summary

smart00717
Location:269 → 316

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:374 → 425

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:378 → 414

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

25223843..25288722

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068224467.1 → XP_068080568.1 metastasis-associated protein MTA3 isoform X1

UniProtKB/TrEMBL

A0A0R4IL54, A0A8M9Q852, E7EY65

Related

ENSDARP00000109572.1, ENSDART00000122665.3
XM_021479999.2 → XP_021335674.1 metastasis-associated protein MTA3 isoform X2

UniProtKB/TrEMBL

A0A8M9QE16

Conserved Domains (4) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:374 → 425

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain
XM_021480000.2 → XP_021335675.1 metastasis-associated protein MTA3 isoform X3

UniProtKB/TrEMBL

A0A8M9QMB6

Conserved Domains (4) summary

cd11661
Location:270 → 315

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:374 → 425

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 171

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:150 → 201

ELM2; ELM2 domain