eomesa eomesodermin homolog a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eomesaprovided by ZNC
Official Full Name: eomesodermin homolog aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001228-1
See related: Ensembl:ENSDARG00000006640 AllianceGenome:ZFIN:ZDB-GENE-001228-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eom; eomes
Summary: Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including determination of dorsal identity; epiboly; and gastrulation. Located in cytoplasm and nucleus. Is expressed in several structures, including blastoderm; blastodisc; brain; eye; and immune system. Orthologous to human EOMES (eomesodermin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (860827..868275, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (861016..868388, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smad2 and Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa forms a general component of the Smad2 signalling complex in zebrafish.
Title: Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression.
Eomesa has a strictly maternal role in the initiation of epiboly, and is required for normal expression of the endoderm markers sox32, bon and og9x; however it is not essential for endoderm formation.
Title: Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A.
Eomes is a Nodal-transducing factor that acts, directly and indirectly, in concert with FoxH1 to carry out all Nodal-dependent processes during early mesendoderm specification.
Title: Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin.
regulates the expression of a zygotic homeobox transcription factor mtx2
Title: T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish.
These results suggest that both Eomes genes are involved in the zebrafish immune response, particularly in lymphocyte function as has been found in mammals.
Title: Expression analysis of two Eomesodermin homologues in zebrafish lymphoid tissues and cells.
Eomes plays a role in specifying the embryonic organizer.
Title: The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation.
Results suggest that eomesodermin promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcriptional activating complex on the casanova promoter.
Title: Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within invagination involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesendoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesoderm formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eomesodermin homolog a

Names: eom-a; eomes1; tbr2; tbr2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131679.3 → NP_571754.3 eomesodermin homolog a

See identical proteins and their annotated locations for NP_571754.3

Status: PROVISIONAL

Source sequence(s)

BC067719

UniProtKB/TrEMBL

A8KBQ6, F6NMT3, Q98TU2

Related

ENSDARP00000111994.1, ENSDART00000122257.3

Conserved Domains (2) summary

cd00182
Location:210 → 403

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

pfam16176
Location:425 → 659

T-box_assoc; T-box transcription factor-associated

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

860827..868275 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159319.5 → XP_005159376.1 eomesodermin homolog a isoform X1

See identical proteins and their annotated locations for XP_005159376.1

UniProtKB/TrEMBL

A8KBQ6, F6NMT3, Q98TU2

Related

ENSDARP00000146371.1, ENSDART00000186626.1

Conserved Domains (2) summary

cd00182
Location:210 → 403

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

pfam16176
Location:425 → 659

T-box_assoc; T-box transcription factor-associated