dvl3a dishevelled segment polarity protein 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dvl3aprovided by ZNC
Official Full Name: dishevelled segment polarity protein 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010319-1
See related: Ensembl:ENSDARG00000015707 AllianceGenome:ZFIN:ZDB-GENE-010319-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dvl3; wu:fb75f04; wu:fi22h02; wu:fp61b09
Summary: Predicted to enable frizzled binding activity. Involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (9702055..9744083, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (9904235..9946263, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal transcripts for dvl2 and dvl3a are most abundantly expressed, whereas the transcript levels of other dvl genes are negligible. Dvl2 and Dvl3a products are required for the activation of zygotic Wnt/ss-catenin signaling and Wnt/planar cell polarity pathway, and regulate zygotic developmental processes in a dosage-dependent manner.
Title: Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb75f04.x1 (e-PCR)
- UniSTS:191254

fb75f04.x1 (e-PCR)
- UniSTS:191255

fl24f02.x1 (e-PCR)
- UniSTS:202091

fi22h02.x1 (e-PCR)
- UniSTS:197053

fj77h03.x1 (e-PCR)
- UniSTS:199878

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: segment polarity protein dishevelled homolog DVL-3a

Names: dishevelled 3; dishevelled, dsh homolog 3; dishevelled, dsh homolog 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131757.2 → NP_571832.2 segment polarity protein dishevelled homolog DVL-3a

Status: VALIDATED

Source sequence(s)

CU633992, CU638697, EB922958, EH447762

UniProtKB/TrEMBL

A0A8M1PC23, B8JMI2

Related

ENSDARP00000088503.4, ENSDART00000097732.6

Conserved Domains (5) summary

smart00021
Location:1 → 82

DAX; Domain present in Dishevelled and axin

cd00992
Location:253 → 340

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:419 → 502

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:88 → 251

Dishevelled; Dishevelled specific domain

pfam12316
Location:506 → 669

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal