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    phb prohibitin [ Danio rerio (zebrafish) ]

    Gene ID: 321346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phbprovided by ZNC
    Official Full Name
    prohibitinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6577
    See related
    Ensembl:ENSDARG00000057414 AllianceGenome:ZFIN:ZDB-GENE-030131-6577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa18f07; fb09f05; sr:nyz128; wu:fa18f07; wu:fb09f05
    Summary
    Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and musculature system. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See phb in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15736884..15746995)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15587000..15597197)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene proline-rich transmembrane protein 2 Neighboring gene major vault protein Neighboring gene zinc finger protein 652 Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities. De Meulemeester AS, et al. Front Cell Dev Biol, 2022. PMID 36238691, Free PMC Article
    2. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
    3. Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Hoffmann JL, et al. Aquat Toxicol, 2006 Sep 12. PMID 16872691
    4. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923
    5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prohibitin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201297.1 → NP_958454.1  prohibitin 1

      See identical proteins and their annotated locations for NP_958454.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055384
      UniProtKB/TrEMBL
      A0A0B5JQ92, A0A8M2BB12, F6NM96, Q7T1D8
      Related
      ENSDARP00000074525.4, ENSDART00000080075.5
      Conserved Domains (2) summary
      smart00244
      Location:25 → 186
      PHB; prohibitin homologues
      cd03401
      Location:26 → 220
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      15736884..15746995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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