twsg1a twisted gastrulation BMP signaling modulator 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: twsg1aprovided by ZNC
Official Full Name: twisted gastrulation BMP signaling modulator 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010509-2
See related: Ensembl:ENSDARG00000104244 AllianceGenome:ZFIN:ZDB-GENE-010509-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tsg; tsga; twsg1; fi23f01; wu:fi23f01
Summary: Acts upstream of or within blood vessel development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (54798689..54833039)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (55065784..55099946)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that in endothelial cells, bone morphogenetic protein endothelial precursor-derived regulator (BMPER) and twisted gastrulation protein homolog 1 (TWSG1) are necessary for regular Notch signaling activity.
Title: Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells.
Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms
Title: Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: twisted gastrulation protein homolog 1-A

Names: twisted gastrulation 1; twisted gastrulation a; twisted gastrulation homolog 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.