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    ankfy1 ankyrin repeat and FYVE domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ankfy1provided by ZNC
    Official Full Name
    ankyrin repeat and FYVE domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041222-1
    See related
    Ensembl:ENSDARG00000061013 AllianceGenome:ZFIN:ZDB-GENE-041222-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb69g03
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport and retrograde transport, endosome to Golgi. Predicted to be active in endosome membrane. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ankfy1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (30996299..31030843)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (30396129..30430687)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495599 Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) Neighboring gene ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast) Neighboring gene cytochrome b5 domain containing 2 Neighboring gene zinc finger, ZZ-type with EF hand domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rabankyrin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102672.1 → NP_001096142.1  rabankyrin-5

      Status: PROVISIONAL

      Source sequence(s)
      CR753844
      UniProtKB/TrEMBL
      A0A8M1NEE8, A2CER9
      Related
      ENSDARP00000148407.1, ENSDART00000185783.1
      Conserved Domains (7) summary
      smart00225
      Location:73 → 160
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:171 → 239
      BACK; BTB And C-terminal Kelch
      cd00204
      Location:864 → 990
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1098 → 1160
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:64 → 160
      BTB; BTB/POZ domain
      pfam12796
      Location:908 → 1001
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:906 → 934
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      30996299..31030843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171905.5 → XP_005171962.1  rabankyrin-5 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IK06, A0A8M2BJB2
      Related
      ENSDARP00000136220.2, ENSDART00000161765.3
      Conserved Domains (7) summary
      smart00225
      Location:73 → 160
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:171 → 239
      BACK; BTB And C-terminal Kelch
      cd00204
      Location:864 → 990
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1099 → 1161
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:64 → 160
      BTB; BTB/POZ domain
      pfam12796
      Location:908 → 1001
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:906 → 934
      ANK; ANK repeat [structural motif]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394583.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      280233..312309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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