dct dopachrome tautomerase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dctprovided by ZNC
Official Full Name: dopachrome tautomeraseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000508-1
See related: Ensembl:ENSDARG00000006008 AllianceGenome:ZFIN:ZDB-GENE-000508-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trp2; TRP-2; zgc:109860
Summary: Predicted to enable dopachrome isomerase activity. Acts upstream of or within melanin metabolic process. Predicted to be located in melanosome membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; female organism; immature eye; integument; and neural crest. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (53327644..53352682)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (53788137..53813085)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dopachrome isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopachrome isomerase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in melanin biosynthetic process from tyrosine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventricular zone neuroblast division	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: L-dopachrome tautomerase

Names: tyrosinase-related protein-2

NP_571630.2

EC 5.3.3.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.