bnip3lb BCL2 interacting protein 3 like b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bnip3lbprovided by ZNC
Official Full Name: BCL2 interacting protein 3 like bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040325-1
See related: Ensembl:ENSDARG00000028067 AllianceGenome:ZFIN:ZDB-GENE-040325-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nip3; bnip3l; zgc:110478
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within heart looping; negative regulation of heart contraction; and positive regulation of apoptotic process. Predicted to be located in membrane and mitochondrial envelope. Predicted to be active in endoplasmic reticulum; mitochondrial outer membrane; and nuclear envelope. Is expressed in several structures, including brain; optic cup; pectoral fin bud; pronephric duct; and somite. Orthologous to human BNIP3L (BCL2 interacting protein 3 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (18911174..18935945)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (18953740..18978511)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nip3a expression was readily detected in 80% epiboly BMP4-Nip3a-injected embryos, and defects in heart development were observed in both the linear heart tube and subsequent chamber formation stages.
Title: Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction.

Submit: New GeneRIF Correction

General gene information

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Markers

fj82b08.x1 (e-PCR)
- UniSTS:200017

fj78h11.y1 (e-PCR)
- UniSTS:199911

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial outer membrane permeabilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BCL2 interacting protein 3 like b

Names: BCL2/adenovirus E1B interacting protein 3-like b; BCL2/adenovirus E1b 19 kDa interacting protein 3a; nip3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.