mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtrprovided by ZNC
Official Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031001-5
See related: Ensembl:ENSDARG00000104906 AllianceGenome:ZFIN:ZDB-GENE-031001-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb830
Summary: Predicted to enable cobalamin binding activity; methionine synthase activity; and zinc ion binding activity. Predicted to act upstream of or within methionine biosynthetic process; methylation; and pteridine-containing compound metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including anterior neural tube; central nervous system; digestive system; immature eye; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (47081695..47116074)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (47134939..47164436)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cobalamin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine synthase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in homocysteine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pteridine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methionine synthase

NP_932338.1

EC 2.1.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198072.1 → NP_932338.1 methionine synthase

See identical proteins and their annotated locations for NP_932338.1

Status: PROVISIONAL

Source sequence(s)

AF506733

UniProtKB/TrEMBL

Q8JIY6

Related

ENSDARP00000139035.2, ENSDART00000158568.2

Conserved Domains (5) summary

COG0646
Location:19 → 337

MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]

PRK09490
Location:13 → 1259

metH; B12-dependent methionine synthase; Provisional

cd00740
Location:369 → 625

MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...

cd02069
Location:669 → 895

methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).

pfam02965
Location:963 → 1243

Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain