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    TSC22D3 TSC22 domain family member 3 [ Homo sapiens (human) ]

    Gene ID: 1831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TSC22D3provided by HGNC
    Official Full Name
    TSC22 domain family member 3provided by HGNC
    Primary source
    HGNC:HGNC:3051
    See related
    Ensembl:ENSG00000157514 MIM:300506; AllianceGenome:HGNC:3051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIP; GILZ; DSIPI; TSC-22R
    Summary
    This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in fat (RPKM 114.8), appendix (RPKM 102.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TSC22D3 in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (107713221..107775988, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (106149979..106212727, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106956451..107019218, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 3 Neighboring gene FRMPD3 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106804525-106805322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106806121-106806916 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106806917-106807714 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:106842109-106842610 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:106842611-106843110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106843233-106843778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106843779-106844324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20928 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:106876457-106876559 Neighboring gene Sharpr-MPRA regulatory region 15331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29833 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20931 Neighboring gene NANOG hESC enhancer GRCh37_chrX:106943730-106944231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106968611-106969112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106975096-106975705 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:106980023-106980600 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106992672-106993524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106993525-106994376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107017786-107018363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107018364-107018940 Neighboring gene Sharpr-MPRA regulatory region 6089 Neighboring gene nuclear cap binding protein subunit 2 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20934 Neighboring gene Sharpr-MPRA regulatory region 15158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107120928-107121436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107121437-107121945 Neighboring gene midline 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29837 Neighboring gene uncharacterized LOC101928335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107162128-107162628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107162629-107163129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation. Hoppstädter J, et al. Eur J Immunol, 2012 May. PMID 22539300
    2. Glucocorticoid-induced leucine zipper expression is associated with response to treatment and immunoregulation in systemic lupus erythematosus. Mohammadi S, et al. Clin Rheumatol, 2017 Aug. PMID 28601944
    3. Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Malaise O, et al. Arthritis Res Ther, 2016 Oct 4. PMID 27716396, Free PMC Article
    4. GILZ overexpression attenuates endoplasmic reticulum stress-mediated cell death via the activation of mitochondrial oxidative phosphorylation. André F, et al. Biochem Biophys Res Commun, 2016 Sep 16. PMID 27416758
    5. Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia. Venanzi A, et al. Eur J Pharm Sci, 2014 Oct 15. PMID 24993177

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ).
      Title: Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ).
    2. Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.
      Title: Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.
    3. Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
      Title: Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
    4. Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Muller glial galectin-1 expression via HIF-1alpha destabilization.
      Title: Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Müller glial galectin-1 expression via HIF-1α destabilization.
    5. MiR-222-3p ameliorates glucocorticoid-induced inhibition of airway epithelial cell repair through down-regulating GILZ expression.
      Title: MiR-222-3p ameliorates glucocorticoid-induced inhibition of airway epithelial cell repair through down-regulating GILZ expression.
    6. Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
      Title: Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
    7. Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis.
      Title: Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis.
    8. Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation.
      Title: Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation.
    9. Dramatic alterations in GILZ occur in those exposed to a stressor in early life, adulthood or both.
      Title: Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD.
    10. L-GILZ regulates thyroid cancer cell proliferation.
      Title: Long glucocorticoid-induced leucine zipper regulates human thyroid cancer cell proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp313A1123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of activation-induced cell death of T cells IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TSC22 domain family protein 3
    Names
    DSIP-immunoreactive leucine zipper protein
    DSIP-immunoreactive peptide
    TSC-22 related protein
    TSC-22-like protein
    delta sleep-inducing peptide immunoreactor
    glucocorticoid-induced leucine zipper protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015881.2 → NP_001015881.1  TSC22 domain family protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001015881.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      AB025432, AL590423, BQ919216, CR933650
      Consensus CDS
      CCDS35365.1
      UniProtKB/TrEMBL
      B2R4H9
      Related
      ENSP00000361466.4, ENST00000372390.8
      Conserved Domains (1) summary
      pfam01166
      Location:1 → 57
      TSC22; TSC-22/dip/bun family

    2. NM_001318468.1 → NP_001305397.1  TSC22 domain family protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      BX647854, CR933650, DA170687
      Consensus CDS
      CCDS14530.1
      UniProtKB/TrEMBL
      B4DU81
      Related
      ENSP00000314655.4, ENST00000315660.8
      Conserved Domains (1) summary
      pfam01166
      Location:124 → 180
      TSC22; TSC-22/dip/bun family

    3. NM_001318470.1 → NP_001305399.1  TSC22 domain family protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AK092645, CR933650, DA170687
      Consensus CDS
      CCDS14530.1
      UniProtKB/TrEMBL
      B4DU81
      Related
      ENSP00000361459.2, ENST00000372384.6
      Conserved Domains (1) summary
      pfam01166
      Location:124 → 180
      TSC22; TSC-22/dip/bun family

    4. NM_004089.4 → NP_004080.2  TSC22 domain family protein 3 isoform 2

      See identical proteins and their annotated locations for NP_004080.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different 5' end exon compared to transcript variant 1, resulting in an isoform (2) with a different and a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AB025432, AL110191, AL590423, CR933650
      Consensus CDS
      CCDS14531.1
      UniProtKB/Swiss-Prot
      Q5H9S3, Q5JRI9, Q5JRJ2, Q6FIH6, Q8NAI1, Q8WVB9, Q99576, Q9UBN5, Q9UG13
      UniProtKB/TrEMBL
      B3KXT7
      Related
      ENSP00000361474.2, ENST00000372397.6
      Conserved Domains (1) summary
      cd21940
      Location:57 → 134
      ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

    5. NM_198057.3 → NP_932174.1  TSC22 domain family protein 3 isoform 1

      See identical proteins and their annotated locations for NP_932174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AK092669, BM047061, CR933650
      Consensus CDS
      CCDS14530.1
      UniProtKB/TrEMBL
      B4DU81
      Related
      ENSP00000361458.4, ENST00000372383.9
      Conserved Domains (1) summary
      pfam01166
      Location:124 → 180
      TSC22; TSC-22/dip/bun family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      107713221..107775988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      106149979..106212727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99576.2 GenPept UniProtKB/Swiss-Prot:Q99576

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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