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    GADD45GIP1 GADD45G interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 90480, updated on 9-Dec-2024

    Summary

    Official Symbol
    GADD45GIP1provided by HGNC
    Official Full Name
    GADD45G interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:29996
    See related
    Ensembl:ENSG00000179271 MIM:605162; AllianceGenome:HGNC:29996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRG6; mL64; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2
    Summary
    This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in kidney (RPKM 22.3), fat (RPKM 19.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GADD45GIP1 in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12953119..12957223, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13077602..13081710, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13063933..13068037, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14093 Neighboring gene Sharpr-MPRA regulatory region 7930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:13045760-13045865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14095 Neighboring gene FARSA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14096 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13049721-13050470 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:13050707-13051906 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13056454-13057146 Neighboring gene Sharpr-MPRA regulatory region 11818 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:13058093-13059292 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:13063321-13064520 Neighboring gene microRNA 6515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13067513-13068385 Neighboring gene calreticulin Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13079936-13080539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13080540-13081142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13085246-13085752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13095227-13095752 Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13106570-13107158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13121583-13122126 Neighboring gene uncharacterized LOC107985286 Neighboring gene nuclear factor I X

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4667, MGC4758

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    large ribosomal subunit protein mL64
    Names
    39S ribosomal protein L59, mitochondrial
    CKII beta binding protein 2
    CKII beta-associating protein
    CR6 interacting factor 1
    growth arrest and DNA damage-inducible proteins-interacting protein 1
    growth arrest and DNA-damage-inducible, gamma interacting protein 1
    growth arrest- and DNA damage-inducible GADD45G-interacting protein
    mitochondrial large ribosomal subunit protein CRIF1
    mitochondrial large ribosomal subunit protein mL64
    p53-responsive gene 6 protein
    papillomavirus L2 interacting nuclear protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052850.4NP_443082.2  large ribosomal subunit protein mL64

      See identical proteins and their annotated locations for NP_443082.2

      Status: REVIEWED

      Source sequence(s)
      AC092069, AF479749, AI309741
      Consensus CDS
      CCDS12290.1
      UniProtKB/Swiss-Prot
      Q8IVM3, Q8TAE8, Q8TE51, Q969P9, Q9BSM6
      Related
      ENSP00000323065.1, ENST00000316939.3
      Conserved Domains (1) summary
      pfam10147
      Location:48190
      CR6_interact; Growth arrest and DNA-damage-inducible proteins-interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12953119..12957223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      13077602..13081710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)