LIMK1 LIM domain kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LIMK1provided by FlyBase
Official Full Name: LIM domain kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0283712
Locus tag: Dmel_CG1848
See related: AllianceGenome:FB:FBgn0283712
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ag; agn; CG1848; D-Limk; D-LIMK1; dLIMK; Dlimk; DLIMK; dLIMK1; DLIMK1; Dmel\CG1848; l(1)11Af; LIM-kinase 1; limk; Limk; LimK; LIMK; LIMK-1; limk1; limK1; Limk1; LimK1; ts398
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including compound eye development; nervous system development; and regulation of axonogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in adult central complex; organism; and visual system. Used to study Williams-Beuren syndrome. Orthologous to human LIMK1 (LIM domain kinase 1) and LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11B2-11B2; 1-39 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12584385..12592193, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12478418..12486226, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of the limk1 Gene in Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males.
Title: Overexpression of the limk1 Gene in Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males.
Genetic analysis in Drosophila midgut revealed a conserved role for dLIMK in constraining gastrointestinal stem cell proliferation.
Title: Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.
functional connections at the behavioral level (learning/memory) depending on the GDNF and LIMK1 brain expression and HSPs transduction that might provide targets for complex approaches for the neurodegenerative diseases treatment.
Title: [Participation of GDNF, LIMK1 signal pathways and heat shock proteins in processes of Drosophila learning and memory formation].
Rac may signal through Pak and LIMK to result in uniform phosphorylation of cofilin in all the outer border cells.
Title: Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis.
The higher resistance of characterictics of behavior and communicative sound signals to heat shock is in agreement with the fact that the extremely high LIMK1 and P-cofilin concentrations in cells go down to normal values after heat shock.
Title: [Courtship behavior, communicative sound production and resistance to stress in Drosophila mutants with defective agnostic gene, coding for LIMK1].
LIMK1 localizes near synaptic microtubules, highlighting a novel requirement for LIMK1 during synapse stabilization
Title: LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor.
Limk is a critical regulator of cofilin function and synapse development, and a downstream effector of p21-activated kinase (Pak) in vivo.
Title: Lim kinase regulates the development of olfactory and neuromuscular synapses.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LIM domain kinase 1

Names: CG1848-PA; CG1848-PC; CG1848-PD; CG1848-PE; CG1848-PF; LIM Kinase1; LIM domain protein kinase; LIM kinase 1; LIM-DOMAIN KINASE; LIM-kinase; LIM-kinase 1; LIM-kinase1; LIMK1-PA; LIMK1-PC; LIMK1-PD; LIMK1-PE; LIMK1-PF; Lim kinase; agnostic; im kinase

NP_001162733.1

EC 2.7.11.1

NP_001162734.1

EC 2.7.11.1

NP_511139.2

EC 2.7.11.1

NP_727621.1

EC 2.7.11.1

NP_727622.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12584385..12592193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078584.3 → NP_511139.2 LIM domain kinase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511139.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IR78, Q8IR79, Q9GV18, Q9GV19, Q9VYL6

UniProtKB/TrEMBL

A0A650FA03, A0A650FBE4

Related

FBpp0073493

Conserved Domains (4) summary

cd09364
Location:33 → 88

LIM1_LIMK; The first LIM domain of LIMK (LIM domain Kinase )

cd09365
Location:95 → 148

LIM2_LIMK; The second LIM domain of LIMK (LIM domain Kinase )

cd00992
Location:172 → 271

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14154
Location:407 → 693

STKc_LIMK; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase
NM_167327.2 → NP_727622.1 LIM domain kinase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727622.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAB4, H5V8E7

Related

FBpp0073494

Conserved Domains (2) summary

cd00992
Location:27 → 66

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14154
Location:202 → 488

STKc_LIMK; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase
NM_167326.2 → NP_727621.1 LIM domain kinase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727621.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A650FA57, E1JJM7

Related

FBpp0073492

Conserved Domains (4) summary

cd09364
Location:33 → 88

LIM1_LIMK; The first LIM domain of LIMK (LIM domain Kinase )

cd09365
Location:95 → 148

LIM2_LIMK; The second LIM domain of LIMK (LIM domain Kinase )

cd00992
Location:172 → 249

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14154
Location:385 → 671

STKc_LIMK; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase
NM_001169263.1 → NP_001162734.1 LIM domain kinase 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162734.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A650FA28, E1JJM8

Conserved Domains (2) summary

cd00992
Location:18 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14154
Location:193 → 479

STKc_LIMK; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase
NM_001169262.1 → NP_001162733.1 LIM domain kinase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162733.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A650FA57, E1JJM7

Conserved Domains (4) summary

cd09364
Location:33 → 88

LIM1_LIMK; The first LIM domain of LIMK (LIM domain Kinase )

cd09365
Location:95 → 148

LIM2_LIMK; The second LIM domain of LIMK (LIM domain Kinase )

cd00992
Location:172 → 249

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14154
Location:385 → 671

STKc_LIMK; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase