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    Naa35 N(alpha)-acetyltransferase 35 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa35provided by FlyBase
    Official Full Name
    N(alpha)-acetyltransferase 35provided by FlyBase
    Primary source
    FLYBASE:FBgn0034982
    Locus tag
    Dmel_CG4065
    See related
    AllianceGenome:FB:FBgn0034982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Nelson1; CG4065; Dmel\CG4065
    Summary
    Predicted to be involved in negative regulation of apoptotic process. Part of NatC complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naa35 in Genome Data Viewer
    Location:
    60B12-60B12; 2-106 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24135180..24138050, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20022703..20025573, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tamo Neighboring gene long non-coding RNA:CR44826 Neighboring gene Zinc finger protein RP-8 Neighboring gene speck Neighboring gene DnaJ-like-60 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Varland S, et al. Nat Commun, 2023 Oct 27. PMID 37891180, Free PMC Article
    2. Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Rathore OS, et al. Sci Rep, 2016 Feb 10. PMID 26861501, Free PMC Article
    3. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article
    4. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article
    5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N(alpha)-acetyltransferase 35
    Names
    CG4065-PA
    CG4065-PB
    Naa35-PA
    Naa35-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24135180..24138050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014546.2 → NP_001014546.1  N(alpha)-acetyltransferase 35, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014546.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8E9
      Conserved Domains (1) summary
      pfam04112
      Location:95 → 229
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    2. NM_138047.3 → NP_611891.1  N(alpha)-acetyltransferase 35, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611891.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q59E64, Q8T3X5, Q9W1A2
      Related
      FBpp0072187
      Conserved Domains (1) summary
      pfam04112
      Location:96 → 230
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1A2.1 Q9W1A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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