NANS N-acetylneuraminic acid synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: NANSprovided by FlyBase
Official Full Name: N-acetylneuraminic acid synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0038045
Locus tag: Dmel_CG5232
See related: AllianceGenome:FB:FBgn0038045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5232; Dmel\CG5232; DmSAS; Nans; Neu5Ac; sas; Sas; SAS
Summary: Enables N-acylneuraminate-9-phosphate synthase activity. Involved in N-acetylneuraminate biosynthetic process and glycosylation. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Orthologous to human NANS (N-acetylneuraminate synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12426578..12427877)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8252300..8253599)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

SAS is a key enzyme in the biosynthesis of sialic acids in Dm CNS neurons
Title: DmSAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acylneuraminate-9-phosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylneuraminate-9-phosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-acetylneuraminate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein glycosylation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

Names: CG5232-PA; N-acetylneuraminic acid phosphate synthase; NANS-PA; Neu5Ac synthase; sialic acid phosphate synthase; sialic acid synthase

NP_650195.1

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The following sections contain reference sequences that belong to a specific genome build. Explain