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    MED15 Mediator complex subunit 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33223, updated on 17-Dec-2024

    Summary

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    Official Symbol
    MED15provided by FlyBase
    Official Full Name
    Mediator complex subunit 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0027592
    Locus tag
    Dmel_CG4184
    See related
    AllianceGenome:FB:FBgn0027592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arc105; BcDNA:GH03922; CG4184; dARC105; Dmel\CG4184; med15; Med15; Med9/ARC105
    Summary
    Predicted to enable transcription coregulator activity. Involved in follicle cell of egg chamber development. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED15 in Genome Data Viewer
    Location:
    21D1-21D1; 2-1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (473013..476170)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (473013..476170)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene u-shaped Neighboring gene cabut Neighboring gene long non-coding RNA:CR46258

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation. Rodriguez I. PLoS One, 2011 Apr 8. PMID 21494610, Free PMC Article
    2. Transcriptional cofactors display specificity for distinct types of core promoters. Haberle V, et al. Nature, 2019 Jun. PMID 31092928, Free PMC Article
    3. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923
    4. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Oh H, et al. Cell Rep, 2013 Feb 21. PMID 23395637, Free PMC Article
    5. Transcription regulation and animal diversity. Levine M, et al. Nature, 2003 Jul 10. PMID 12853946

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 15
    Names
    CG4184-PA
    MED15-PA
    mediator15

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      473013..476170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134684.3 → NP_608528.1  mediator complex subunit 15 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y149
      Related
      FBpp0077722
      Conserved Domains (1) summary
      pfam09606
      Location:12 → 749
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y149.1 Q9Y149

    Gene LinkOut

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