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    CG7049 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7049provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035102
    Locus tag
    Dmel_CG7049
    See related
    AllianceGenome:FB:FBgn0035102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7049
    Summary
    Predicted to enable formylglycine-generating oxidase activity. Predicted to be involved in protein modification process. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7049 in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (175112..176228, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (175112..176228, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dynein intermediate chain at 61B Neighboring gene p130CAS Neighboring gene long non-coding RNA:CR43151 Neighboring gene antisense RNA:CR45806 Neighboring gene Vitamin D[[3]] up-regulated protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MAP kinase-specific phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dcas supports cell polarization and cell-cell adhesion complexes in development. Tikhmyanova N, et al. PLoS One, 2010 Aug 24. PMID 20808771, Free PMC Article
    2. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables formylglycine-generating oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formylglycine-generating oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7049-PA
    NP_612003.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      175112..176228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138159.4 → NP_612003.1  uncharacterized protein Dmel_CG7049 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QPQ4, Q9W0U6
      Related
      FBpp0072436
      Conserved Domains (2) summary
      COG1262
      Location:65 → 336
      YfmG; Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones]
      pfam03781
      Location:65 → 334
      FGE-sulfatase; Sulfatase-modifying factor enzyme 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T058 Q8T058
    Q9W0U6 Q9W0U6

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