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    mthl3 methuselah-like 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36961, updated on 9-Dec-2024

    Summary

    Official Symbol
    mthl3provided by FlyBase
    Official Full Name
    methuselah-like 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028956
    Locus tag
    Dmel_CG6530
    See related
    AllianceGenome:FB:FBgn0028956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    104/8; anon-WO0170980.52; anon-WO0170980.53; BEST:GM02553; CG6530; Dmel\CG6530; gene 1; GENE 1; l(2)k10408; Mth-3; mthl-3; Mthl3
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic abdominal neuromere; eye disc morphogenetic furrow; and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mthl3 in Genome Data Viewer
    Location:
    54B16-54B16; 2-82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17448533..17452598, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13336038..13340103, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Egg-derived tyrosine phosphatase Neighboring gene uncharacterized protein Neighboring gene methuselah-like 4 Neighboring gene uncharacterized protein Neighboring gene roadblock similar 54B

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    methuselah-like 3
    Names
    CG6530-PA
    CG6530-PB
    CG6530-PC
    Methuselah-like 3
    Mth-like 3
    mthl3-PA
    mthl3-PB
    mthl3-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17448533..17452598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_145335.3NP_663308.1  methuselah-like 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_663308.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V818
      UniProtKB/TrEMBL
      A0A0B4LFS2, Q6NNZ3
      Related
      FBpp0086111
      Conserved Domains (2) summary
      pfam06652
      Location:26204
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:216436
      7tm_4; Olfactory receptor
    2. NM_001299597.1NP_001286526.1  methuselah-like 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V818
      UniProtKB/TrEMBL
      A0A0B4LFS2, Q6NNZ3
      Conserved Domains (2) summary
      pfam06652
      Location:26204
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:216436
      7tm_4; Olfactory receptor
    3. NM_001299598.1NP_001286527.1  methuselah-like 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286527.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V818
      UniProtKB/TrEMBL
      A0A0B4LFS2, Q6NNZ3
      Conserved Domains (2) summary
      pfam06652
      Location:26204
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:216436
      7tm_4; Olfactory receptor