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    Svip small VCP interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Svipprovided by FlyBase
    Official Full Name
    small VCP interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052039
    Locus tag
    Dmel_CG32039
    See related
    AllianceGenome:FB:FBgn0052039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE03722; BEST:GH02734; CG32039; Dmel\CG32039; SVIP
    Summary
    Involved in autophagosome-lysosome fusion and lysosomal membrane organization. Located in lysosomal membrane. Orthologous to human SVIP (small VCP interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Svip in Genome Data Viewer
    Location:
    67B2-67B2; 3-29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9358999..9359996)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9352099..9353096)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peptidoglycan recognition protein LF Neighboring gene UDP-glucose pyrophosphorylase Neighboring gene uncharacterized protein Neighboring gene Pyridoxal kinase Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 67A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tubular lysosome induction couples animal starvation to healthy aging. Villalobos TV, et al. Nat Aging, 2023 Sep. PMID 37580394, Free PMC Article
    2. SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan. Johnson AE, et al. Nat Commun, 2021 Jan 21. PMID 33479240, Free PMC Article
    3. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Vinayagam A, et al. Nat Methods, 2014 Jan. PMID 24240319, Free PMC Article
    4. The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster. Nazario-Toole AE, et al. J Immunol, 2018 Aug 15. PMID 29997126, Free PMC Article
    5. Hundreds of putatively functional small open reading frames in Drosophila. Ladoukakis E, et al. Genome Biol, 2011 Nov 25. PMID 22118156, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosomal membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small VCP interacting protein
    Names
    CG32039-PA
    CG32039-PB
    Svip-PA
    Svip-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9358999..9359996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300069.1 → NP_001286998.1  small VCP interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286998.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQC6
      Conserved Domains (1) summary
      pfam15811
      Location:1 → 78
      SVIP; Small VCP/p97-interacting protein

    2. NM_168327.3 → NP_729471.1  small VCP interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQC6
      Related
      FBpp0076169
      Conserved Domains (1) summary
      pfam15811
      Location:1 → 78
      SVIP; Small VCP/p97-interacting protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQC6 Q8IQC6
    Q8MZ33 Q8MZ33

    Gene LinkOut

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