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    Qsox4 Quiescin sulfhydryl oxidase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qsox4provided by FlyBase
    Official Full Name
    Quiescin sulfhydryl oxidase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0051413
    Locus tag
    Dmel_CG31413
    See related
    AllianceGenome:FB:FBgn0051413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10299; CG31413; Dmel\CG31413; QSox4
    Summary
    Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Predicted to be active in Golgi membrane and extracellular space. Is expressed in adult head. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Qsox4 in Genome Data Viewer
    Location:
    95A8-95A9; 3-80 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23702761..23704542)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19528483..19530264)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glucocerebrosidase 1a Neighboring gene Glucocerebrosidase 1b Neighboring gene antisense RNA:CR44052 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration. Davis MY, et al. PLoS Genet, 2016 Mar. PMID 27019408, Free PMC Article
    2. Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks. Ayroles JF, et al. Genet Res (Camb), 2011 Dec. PMID 22189604, Free PMC Article
    3. Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster. Sepil I, et al. Mol Cell Proteomics, 2019 Mar 15. PMID 30287546, Free PMC Article
    4. BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions. Hopkins BR, et al. Proc Natl Acad Sci U S A, 2019 Dec 3. PMID 31740617, Free PMC Article
    5. The evolution of seminal fluid gene expression and postmating reproductive isolation in Drosophila. Flacchi C, et al. Evolution, 2024 May 1. PMID 38416119

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quiescin sulfhydryl oxidase 4
    Names
    CG31413-PA
    Qsox4-PA
    NP_732891.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23702761..23704542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170084.3 → NP_732891.1  quiescin sulfhydryl oxidase 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QV0, Q8IMY4
      Related
      FBpp0083834
      Conserved Domains (2) summary
      cd02992
      Location:32 → 145
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:425 → 512
      Evr1_Alr; Erv1 / Alr family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMY4 Q8IMY4

    Gene LinkOut

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