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    Oda Ornithine decarboxylase antizyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Odaprovided by FlyBase
    Official Full Name
    Ornithine decarboxylase antizymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014184
    Locus tag
    Dmel_CG16747
    See related
    AllianceGenome:FB:FBgn0014184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AZ; CG16747; D-AZ; Dmel\CG16747; guf; l(2)02833; l(2)k09037; oda; ODA
    Summary
    Predicted to enable ornithine decarboxylase inhibitor activity. Predicted to be involved in positive regulation of protein catabolic process. Located in cytosol and nucleoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult CNS glial cell; adult brain cell body rind; fat body primordium; and gut section. Human ortholog(s) of this gene implicated in coronary restenosis. Orthologous to human OAZ1 (ornithine decarboxylase antizyme 1); OAZ2 (ornithine decarboxylase antizyme 2); and OAZ3 (ornithine decarboxylase antizyme 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oda in Genome Data Viewer
    Location:
    48E4-48E4; 2-66 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12166295..12174264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8053800..8061769, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46194 Neighboring gene Small ribonucleoprotein particle protein SmD3 Neighboring gene mir-281-2 stem loop Neighboring gene mir-281-1 stem loop Neighboring gene Chaperonin containing TCP1 subunit 5 Neighboring gene antisense RNA:CR45264 Neighboring gene Endonuclease G Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of nuclear export signals in antizyme-1. Murai N, et al. J Biol Chem, 2003 Nov 7. PMID 12941943
    2. The Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand. Ivanov IP, et al. Mol Cell Biol, 1998 Mar. PMID 9488472, Free PMC Article
    3. P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine Decarboxylase Antizyme gene affect only the expression of SmD3. Schenkel H, et al. Genetics, 2002 Jun. PMID 12072471, Free PMC Article
    4. Independent transcription of miR-281 in the intron of ODA in Drosophila melanogaster. Xiong H, et al. Biochem Biophys Res Commun, 2009 Jan 23. PMID 19073139
    5. Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Ivanov IP, et al. Nucleic Acids Res, 2000 Sep 1. PMID 10954585, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The abundance of miR-281 does not correlate, either positively or negatively, with the expression of any ornithine decarboxylase antizyme (ODA) isoform, indicating that ODA has little influence on the transcription of miR-281.
      Title: Independent transcription of miR-281 in the intron of ODA in Drosophila melanogaster.
    2. Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis.
      Title: Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ornithine decarboxylase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme
    Names
    CG16747-PA
    CG16747-PB
    CG16747-PC
    Oda-PA
    Oda-PB
    Oda-PC
    antizyme
    gut feeling
    gutfeeling
    ornithine deacarboxylase antizyme
    orthinine decarboyxlase antizyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12166295..12174264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165865.3 → NP_725105.1  ornithine decarboxylase antizyme, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8U2
      Related
      FBpp0087123
      Conserved Domains (1) summary
      pfam02100
      Location:160 → 246
      ODC_AZ; Ornithine decarboxylase antizyme

    2. NM_165863.3 → NP_725103.1  ornithine decarboxylase antizyme, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44436, P54361
      Related
      FBpp0087121
      Conserved Domains (1) summary
      pfam02100
      Location:166 → 252
      ODC_AZ; Ornithine decarboxylase antizyme

    3. NM_165864.3 → NP_725104.1  ornithine decarboxylase antizyme, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8U1
      Related
      FBpp0087122
      Conserved Domains (1) summary
      pfam02100
      Location:182 → 268
      ODC_AZ; Ornithine decarboxylase antizyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8U1 A1Z8U1
    A1Z8U2 A1Z8U2
    P54361.2 P54361
    Q8T0J6 Q8T0J6

    Gene LinkOut

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