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    Poxn Pox neuro [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36741, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Poxnprovided by FlyBase
    Official Full Name
    Pox neuroprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003130
    Locus tag
    Dmel_CG8246
    See related
    AllianceGenome:FB:FBgn0003130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8246; Dmel\CG8246; neuro; P4; pox-n; Pox-n; poxn; Poxn1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adult feeding behavior; imaginal disc-derived appendage morphogenesis; and male courtship behavior. Located in nucleus. Is expressed in several structures, including adult ellipsoid body ring neurons; ganglia; neuromere; sense organ; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Poxn in Genome Data Viewer
    Location:
    52C7-52C7; 2-75 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15826693..15835055, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11714198..11722560, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Z band alternatively spliced PDZ-motif protein 52 Neighboring gene tungus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cGAS-like receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crucial roles of Pox neuro in the developing ellipsoid body and antennal lobes of the Drosophila brain. Minocha S, et al. PLoS One, 2017. PMID 28441464, Free PMC Article
    2. Connectivity of chemosensory neurons is controlled by the gene poxn in Drosophila. Nottebohm E, et al. Nature, 1992 Oct 29. PMID 1436059
    3. Neuronal Constituents and Putative Interactions Within the Drosophila Ellipsoid Body Neuropil. Omoto JJ, et al. Front Neural Circuits, 2018. PMID 30546298, Free PMC Article
    4. Acidic Food pH Increases Palatability and Consumption and Extends Drosophila Lifespan. Deshpande SA, et al. J Nutr, 2015 Dec. PMID 26491123, Free PMC Article
    5. The gene poxn controls different steps of the formation of chemosensory organs in Drosophila. Nottebohm E, et al. Neuron, 1994 Jan. PMID 8292359

    See all (183) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila.
      Title: Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila.
    2. The paired box gene Pox neuro (Poxn) is expressed in two bilaterally symmetric neuronal clusters of the developing adult Drosophila brain, a protocerebral dorsal cluster (DC) and a deutocerebral ventral cluster (VC). The study shows that all cells that express Poxn in the developing brain are postmitotic neurons. Poxn is crucial for pathfinding both in the DC and VC.
      Title: Crucial roles of Pox neuro in the developing ellipsoid body and antennal lobes of the Drosophila brain.
    3. Pox neuro controls cell lineages that give rise to larval poly-innervated external sensory organs in Drosophila.
      Title: Pox neuro control of cell lineages that give rise to larval poly-innervated external sensory organs in Drosophila.
    4. Pox neuro has roles in Drosophila male courtship, fertility, segmentation of the leg disc and antennal disc, and development of the wing hinge
      Title: The Drosophila Pox neuro gene: control of male courtship behavior and fertility as revealed by a complete dissection of all enhancers.
    5. poxn is involved in suppressing bract formation near the chemosensory bristles.
      Title: Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway.
    6. expression in embryonic brain
      Title: An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antennal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to water IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pox neuro
    Names
    CG8246-PA
    CG8246-PB
    Poxn-PA
    Poxn-PB
    paired box neural
    paired box-neuro
    pox neuro
    pox-neural
    pox-neuro

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15826693..15835055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274087.1 → NP_001261016.1  Pox neuro, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23758, Q9V7F3
      UniProtKB/TrEMBL
      Q4V720
      Conserved Domains (1) summary
      cl21459
      Location:5 → 133
      HTH; Helix-turn-helix domains

    2. NM_057338.3 → NP_476686.1  Pox neuro, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23758, Q9V7F3
      UniProtKB/TrEMBL
      Q4V720
      Related
      FBpp0086446
      Conserved Domains (1) summary
      cl21459
      Location:5 → 133
      HTH; Helix-turn-helix domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23758.3 P23758
    Q4V720 Q4V720

    Gene LinkOut

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