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    elm ethanol sensitive with low memory [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elmprovided by FlyBase
    Official Full Name
    ethanol sensitive with low memoryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037358
    Locus tag
    Dmel_CG2185
    See related
    AllianceGenome:FB:FBgn0037358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2185; Dmel\CG2185
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of phospholipid biosynthetic process. Located in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; ganglia; mesoderm; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to several human genes including CHP1 (calcineurin like EF-hand protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See elm in Genome Data Viewer
    Location:
    83B8-83B8; 3-47.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5652640..5654861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1478362..1480583, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Metastasis associated 1-like Neighboring gene Secretory 23 Neighboring gene Mediator complex subunit 27 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44093

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phospholipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ethanol sensitive with low memory
    Names
    CG2185-PA
    CG2185-PB
    Calcineurin2
    elm-PA
    elm-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5652640..5654861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275366.1 → NP_001262295.1  ethanol sensitive with low memory, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K107, Q9VNF9
      Conserved Domains (1) summary
      COG5126
      Location:23 → 173
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_141311.3 → NP_649568.1  ethanol sensitive with low memory, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K107, Q9VNF9
      Related
      FBpp0078381
      Conserved Domains (1) summary
      COG5126
      Location:23 → 173
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K107 Q7K107
    Q9VNF9 Q9VNF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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