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    Bug22 Basal body up regulated gene 22 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bug22provided by FlyBase
    Official Full Name
    Basal body up regulated gene 22provided by FlyBase
    Primary source
    FLYBASE:FBgn0032248
    Locus tag
    Dmel_CG5343
    See related
    AllianceGenome:FB:FBgn0032248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5343; Dmel\CG5343
    Summary
    Involved in several processes, including positive regulation of flagellated sperm motility; protein polyglycylation; and spermatid development. Located in nucleolus and sperm flagellum. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in dorsal sensory complex proper primordium; embryonic head sensory system; organism; sensory nervous system primordium; and ventral sensory complex primordium. Orthologous to human CFAP20 (cilia and flagella associated protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bug22 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10429920..10430918, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10429920..10430918, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Small ribonucleoprotein particle protein SmB Neighboring gene KDEL receptor Neighboring gene uncharacterized protein Neighboring gene Transcription factor IIB Neighboring gene TBC1 domain family member 16 Neighboring gene hole-in-one

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules. Mendes Maia T, et al. Biol Open, 2014 Feb 15. PMID 24414207, Free PMC Article
    2. The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster. Lattao R, et al. Genetics, 2017 May. PMID 28476861, Free PMC Article
    3. Imaging cilia in Drosophila melanogaster. Vieillard J, et al. Methods Cell Biol, 2015. PMID 25837397
    4. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article
    5. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division. Manzanero-Ortiz S, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768763, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyglycylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium beat frequency involved in ciliary motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basal body up regulated gene 22
    Names
    Bug22-PA
    CG5343-PA
    basal body up regulated gene 22 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10429920..10430918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135558.4 → NP_609402.1  basal body up regulated gene 22 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VKV8
      Related
      FBpp0079634
      Conserved Domains (1) summary
      pfam05018
      Location:1 → 185
      DUF667; Protein of unknown function (DUF667)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKV8.1 Q9VKV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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