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    alphaCOP Coat Protein (coatomer) alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38199, updated on 27-Dec-2024

    Summary

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    Official Symbol
    alphaCOPprovided by FlyBase
    Official Full Name
    Coat Protein (coatomer) alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025725
    Locus tag
    Dmel_CG7961
    See related
    AllianceGenome:FB:FBgn0025725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-COP; alphaCop; CG7961; Dmel\CG7961
    Summary
    Predicted to enable structural molecule activity. Involved in male meiosis cytokinesis; protein localization to cleavage furrow; and regulation of lipid storage. Located in endoplasmic reticulum-Golgi intermediate compartment. Part of COPI vesicle coat. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and male germline cell. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alphaCOP in Genome Data Viewer
    Location:
    62A9-62A9; 3-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1641066..1645199, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1641066..1645199, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 2 Neighboring gene Big brother Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Brother

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineered Flock House Virus for Targeted Gene Suppression Through RNAi in Fruit Flies (Drosophila melanogaster) in Vitro and in Vivo. Taning CNT, et al. Front Physiol, 2018. PMID 30018564, Free PMC Article
    2. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. Frappaolo A, et al. J Cell Sci, 2017 Nov 1. PMID 28883096, Free PMC Article
    3. COPI-regulated mitochondria-ER contact site formation maintains axonal integrity. Maddison DC, et al. Cell Rep, 2023 Aug 29. PMID 37498742, Free PMC Article
    4. COPI activity coupled with fatty acid biosynthesis is required for viral replication. Cherry S, et al. PLoS Pathog, 2006 Oct. PMID 17040126, Free PMC Article
    5. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress. Zhang P, et al. Sci Rep, 2016 Feb 18. PMID 26887613, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cleavage furrow IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coat protein (coatomer) alpha
    Names
    CG7961-PA
    CG7961-PB
    COPI alpha subunit
    alpha-coatomer protein
    alphaCOP-PA
    alphaCOP-PB
    coatomer I

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1641066..1645199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167908.3 → NP_728648.1  coat protein (coatomer) alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77285, Q9W0B8
      Related
      FBpp0072693
      Conserved Domains (5) summary
      COG2319
      Location:2 → 320
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:5 → 321
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04053
      Location:354 → 765
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:815 → 1228
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      sd00039
      Location:57 → 91
      7WD40; WD40 repeat [structural motif]

    2. NM_058047.5 → NP_477395.1  coat protein (coatomer) alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77285, Q9W0B8
      Related
      FBpp0072694
      Conserved Domains (5) summary
      COG2319
      Location:2 → 320
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:5 → 321
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04053
      Location:354 → 765
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:815 → 1228
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      sd00039
      Location:57 → 91
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77285 O77285
    Q9W0B8 Q9W0B8

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