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    Ccdc114 Coiled-coil domain containing protein 114 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc114provided by FlyBase
    Official Full Name
    Coiled-coil domain containing protein 114provided by FlyBase
    Primary source
    FLYBASE:FBgn0038452
    Locus tag
    Dmel_CG14905
    See related
    AllianceGenome:FB:FBgn0038452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14905; Dmel\CG14905
    Summary
    Is expressed in chordotonal neurons. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 20. Orthologous to several human genes including CCDC63 (coiled-coil domain containing 63). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ccdc114 in Genome Data Viewer
    Location:
    89D5-89D5; 3-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16622735..16624717, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12448457..12450439, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-2494 stem loop Neighboring gene uncharacterized protein Neighboring gene Fasciclin 1 Neighboring gene nonA-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Jerber J, et al. Hum Mol Genet, 2014 Feb 1. PMID 24067530
    2. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article
    3. Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization. Newton FG, et al. Dev Cell, 2012 Jun 12. PMID 22698283, Free PMC Article
    4. Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex. Gilfillan GD, et al. Genes Dev, 2006 Apr 1. PMID 16547172, Free PMC Article
    5. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Coiled-coil domain containing protein 114
    Names
    CG14905-PA
    Ccdc114-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16622735..16624717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142312.2 → NP_650569.1  Coiled-coil domain containing protein 114 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VES4
      Related
      FBpp0082802
      Conserved Domains (1) summary
      cl02563
      Location:233 → 294
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VES4 Q9VES4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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