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    crc cryptocephal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47767, updated on 17-Dec-2024

    Summary

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    Official Symbol
    crcprovided by FlyBase
    Official Full Name
    cryptocephalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000370
    Locus tag
    Dmel_CG8669
    See related
    AllianceGenome:FB:FBgn0000370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    929; ATF-4; atf4; Atf4; ATF4; ATF4/crc; CG8669; Crc; dATF-4; dAtf4; dATF4; DM6; Dmel\CG8669; Ire1; l(2)crc
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in several processes, including PERK-mediated unfolded protein response; instar larval or pupal development; and positive regulation of JNK cascade. Located in endoplasmic reticulum membrane. Is expressed in several structures, including LNv neurons; embryonic/larval anterior spiracle; embryonic/larval salivary gland; fat body; and ganglia. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to several human genes including ATF5 (activating transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crc in Genome Data Viewer
    Location:
    39C2-39C3; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21310866..21319527)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21310866..21319527)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene mondo Neighboring gene Gustatory receptor 39a Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44785 Neighboring gene long non-coding RNA:CR42696

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Development of the morphological mutant cryptocephal of Drosophila melanogaster. Fristrom JW. Genetics, 1965 Aug. PMID 5861563, Free PMC Article
    2. [Developmental physiology and genetics of the lethal factor crc in Drosophila melanogaster]. GLOOR H. Arch Julius Klaus Stift Vererbungsforsch Sozialanthropol Rassenhyg, 1945. PMID 20276269
    3. The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila. Srivastava A, et al. Front Aging, 2022. PMID 35821827, Free PMC Article
    4. RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle regeneration. Catalani E, et al. Cell Death Discov, 2022 Nov 18. PMID 36396939, Free PMC Article
    5. A Drosophila model of mitochondrial disease phenotypic heterogeneity. Granat L, et al. Biol Open, 2024 Feb 15. PMID 38304969, Free PMC Article

    See all (159) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
      Title: Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
    2. ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila.
      Title: ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila.
    3. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
      Title: Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
    4. ATF4 activation reprograms nuclear gene expression and contributes to neuronal dysfunction
      Title: Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate.
    5. ATF4 regulates the expression of one-carbon metabolism genes SHMT2 and NMDMC as a protective response to mitochondrial toxicity.
      Title: dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
    6. GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
      Title: 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.
    7. Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2.
      Title: Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2.
    8. The roles of crc and dimmed genes on the expression of diverse hormones in D. melanogaster and reported.
      Title: Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21312573-21312651 mobile_element_type = transposon:INE-1{}4067
    • Loc: 21317491-21317796 mobile_element_type = transposon:INE-1{}4069

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coactivator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pupation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cryptocephal
    Names
    CG8669-PA
    CG8669-PB
    CG8669-PE
    CG8669-PF
    crc-PA
    crc-PB
    crc-PE
    crc-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21310866..21319527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273743.1 → NP_001260672.1  cryptocephal, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NIR4, Q9VID3
      Conserved Domains (1) summary
      cd14692
      Location:313 → 374
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    2. NM_080158.3 → NP_524897.1  cryptocephal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NIR4, Q9VID3
      Related
      FBpp0081040
      Conserved Domains (1) summary
      cd14692
      Location:313 → 374
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    3. NM_001273744.1 → NP_001260673.1  cryptocephal, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBF8, Q9NIR4
      Conserved Domains (1) summary
      cd14692
      Location:304 → 365
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    4. NM_165374.2 → NP_724333.1  cryptocephal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NIR3
      Related
      FBpp0081041
      Conserved Domains (1) summary
      cd14692
      Location:230 → 291
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBF8 M9PBF8
    Q9NIR3 Q9NIR3
    Q9NIR4 Q9NIR4
    Q9NIR5 Q9NIR5
    Q9VID3 Q9VID3

    Gene LinkOut

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