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    Stip1 Stress induced phosphoprotein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stip1provided by FlyBase
    Official Full Name
    Stress induced phosphoprotein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024352
    Locus tag
    Dmel_CG2720
    See related
    AllianceGenome:FB:FBgn0024352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2720; dhop; dHop; Dmel\CG2720; dmSTI1; dSTI1; dSTIP1; EP(2)0418; hop; Hop; HOP; l(2)k00616; Sti1; stip1
    Summary
    Predicted to enable Hsp90 protein binding activity. Involved in multivesicular body fusion to apical plasma membrane. Is expressed in adult head. Orthologous to human STIP1 (stress induced phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Stip1 in Genome Data Viewer
    Location:
    21B8-21B8; 2-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (295122..297449)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (295122..297449)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46263 Neighboring gene amnionless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene U2 small nuclear riboprotein auxiliary factor 38 Neighboring gene Pi3K21B Neighboring gene long non-coding RNA:CR43719 Neighboring gene Phospholipase C at 21C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP. Yi F, et al. Protein Sci, 2010 Jan. PMID 19866486, Free PMC Article
    2. Hop: more than an Hsp70/Hsp90 adaptor protein. Odunuga OO, et al. Bioessays, 2004 Oct. PMID 15382137
    3. Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Igaki T, et al. Biochem Biophys Res Commun, 2007 May 18. PMID 17397804
    4. Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation. Carrigan PE, et al. J Biol Chem, 2005 Mar 11. PMID 15632128
    5. Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity. Xu F, et al. Cell Rep, 2019 Apr 2. PMID 30943415, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in multivesicular body fusion to apical plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stress induced phosphoprotein 1
    Names
    CG2720-PA
    Hsp70(Hsp90) organizing protein
    Hsp70-Hsp90 organizing protein
    Hsp70/90-organizing protein homolog
    Hsp70/Hsp90 organizing protein
    Hsp70/Hsp90 organizing protein homolog
    Stip1-PA
    stress inducible protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      295122..297449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058006.4 → NP_477354.1  stress induced phosphoprotein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61650, Q9VPN5
      Related
      FBpp0077790
      Conserved Domains (5) summary
      smart00727
      Location:439 → 478
      STI1; Heat shock chaperonin-binding motif
      sd00006
      Location:310 → 338
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:181 → 208
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:309 → 375
      TPR_11; TPR repeat
      pfam13424
      Location:205 → 278
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61650 O61650
    Q867V1 Q867V1
    Q867Y1 Q867Y1
    Q9VPN5 Q9VPN5

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