GlcAT-S Glucuronyltransferase S [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlcAT-Sprovided by FlyBase
Official Full Name: Glucuronyltransferase Sprovided by FlyBase
Primary source: FLYBASE:FBgn0032135
Locus tag: Dmel_CG3881
See related: AllianceGenome:FB:FBgn0032135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3881; dGlcAT-BSI; dGlcAT-S; DGlcAT-S; Dmel\CG3881; DmGlcAT-BSI
Summary: Enables glucuronosyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in adult head; germarium; hub cell; organism; and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9616469..9623109)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9616469..9623109)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Study confirms results showing that GlcAT-S and GlcAT-P can transfer GlcA to the O-linked T-antigen as well as to N-linked LacNAc-chains in vitro.
Title: Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen.
novel glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans
Title: Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables asioloorosomucoid beta-1,3-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoprotein biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in glycosphingolipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in protein N-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in proteoglycan biosynthetic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_001162922.1

NP_609303.1

NP_723476.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain