U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    net net [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45339, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    netprovided by FlyBase
    Official Full Name
    netprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002931
    Locus tag
    Dmel_CG11450
    See related
    AllianceGenome:FB:FBgn0002931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHc42; CG11450; Dmel\CG11450; Group IId; Net; shout; Shout
    Summary
    Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in imaginal disc-derived wing vein specification and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; dorsal ectoderm; mesoderm; and visceral mesoderm derivative. Orthologous to human ATOH8 (atonal bHLH transcription factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See net in Genome Data Viewer
    Location:
    21B1-21B1; 2-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (82421..87387, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (82421..87387, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44987 Neighboring gene galectin Neighboring gene uncharacterized protein Neighboring gene Zizimin-related Neighboring gene Cysteine rich with EGF like domains Neighboring gene Na[+]/H[+] hydrogen exchanger 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. Hatsumi M, et al. J Cell Sci, 1992 Dec. PMID 1487485
    2. Increased type IV collagenase in lgl-induced invasive tumors of Drosophila. Woodhouse E, et al. Cell Growth Differ, 1994 Feb. PMID 8180128
    3. Hereditary suppression of lethal (2) giant larvae malignant tumor development in Drosophila by gene transfer. Opper M, et al. Oncogene, 1987 May. PMID 2830580
    4. Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system. Akin O, et al. Elife, 2016 Oct 15. PMID 27743477, Free PMC Article
    5. Genetic determinants of glutamine synthetase in Drosophila melanogaster: a gene for glutamine synthetase I resides in the 21B3-6 region. Caggese C, et al. Biochem Genet, 1988 Oct. PMID 2907404

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing vein morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    net
    Names
    CG11450-PB
    CG11450-PC
    net-PB
    net-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      82421..87387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080081.3 → NP_524820.2  net, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524820.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KH24, Q9BMU0, Q9VPI8
      Conserved Domains (1) summary
      pfam00010
      Location:269 → 320
      HLH; Helix-loop-helix DNA-binding domain

    2. NM_001272860.1 → NP_001259789.1  net, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KH24, Q9BMU0, Q9VPI8
      Conserved Domains (1) summary
      pfam00010
      Location:269 → 320
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KH24 Q7KH24
    Q9VPI8 Q9VPI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools