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    Act88F Actin 88F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41885, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Act88Fprovided by FlyBase
    Official Full Name
    Actin 88Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000047
    Locus tag
    Dmel_CG5178
    See related
    AllianceGenome:FB:FBgn0000047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    act 88F; Act(88F); Act88-F; act88F; Act88f; ACT88F; actin; Actin; Actin88F; ArpD; CG5178; Dmel\CG5178; E; Ifm(3)7; P83967; rsd
    Summary
    Involved in muscle thin filament assembly. Located in Z disc. Is expressed in several structures, including adult head; adult somatic muscle cell of thorax; spermatozoon; thoracic adult muscle precursor cell; and wing blade. Used to study congenital structural myopathy; myopathy; and nemaline myopathy. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Act88F in Genome Data Viewer
    Location:
    88F5-88F5; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15439969..15442177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11265691..11267899)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45911 Neighboring gene mir-2c stem loop Neighboring gene uncharacterized protein Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif A Neighboring gene snoRNA:Orphan H/ACA box 9 Neighboring gene B9d1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate a role for CF2 as a direct negative regulator of the thin filament protein gene Actin 88F.
      Title: CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila.
    2. Results report on the structure and in situ location of arthrin (monoubiquitinated actin).
      Title: Structural studies of arthrin: monoubiquitinated actin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle thin filament HDA PubMed 

    General protein information

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    Preferred Names
    actin 88F
    Names
    88F actin
    Act88F-PA
    CG5178-PA
    F-actin
    actin
    actin88F
    arthrin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15439969..15442177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079643.2 → NP_524367.1  actin 88F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83967
      UniProtKB/TrEMBL
      B6IDW7, C6TP14
      Related
      FBpp0082597
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83967.1 P83967

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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