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    COX7AL2 Cytochrome c oxidase subunit 7A-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX7AL2provided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 7A-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0085201
    Locus tag
    Dmel_CG34172
    See related
    AllianceGenome:FB:FBgn0085201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34172; COX7A2; Dmel\CG34172; Q6IHY5
    Summary
    Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be part of respiratory chain complex. Is expressed in adult head. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1); COX7A2 (cytochrome c oxidase subunit 7A2); and COX7A2L (cytochrome c oxidase subunit 7A2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX7AL2 in Genome Data Viewer
    Location:
    22D1-22D1; 2-5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2192525..2197912, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2192525..2197912, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45290 Neighboring gene antisense RNA:CR44065 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila. Jiang MD, et al. Brain Res Bull, 2017 Jun. PMID 28625786
    2. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
    3. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Rahman A, et al. Cell Rep, 2022 May 31. PMID 35649355, Free PMC Article
    4. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
    5. Cardiolipin prolongs the lifetimes of respiratory proteins in Drosophila flight muscle. Ren M, et al. J Biol Chem, 2023 Oct. PMID 37690688, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7A-like 2
    Names
    CG34172-PA
    CG34172-PB
    CG34172-PC
    CG34172-PD
    COX7AL2-PA
    COX7AL2-PB
    COX7AL2-PC
    COX7AL2-PD
    cytochrome c oxidase subunit 7A1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2192525..2197912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272983.1 → NP_001259912.1  cytochrome c oxidase subunit 7A-like 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IHY5
      Conserved Domains (1) summary
      cd00928
      Location:3 → 57
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001258917.1 → NP_001245846.1  cytochrome c oxidase subunit 7A-like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IHY5
      Conserved Domains (1) summary
      cd00928
      Location:3 → 57
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_001103584.1 → NP_001097054.1  cytochrome c oxidase subunit 7A-like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IHY5
      Conserved Domains (1) summary
      cd00928
      Location:3 → 57
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_001272984.1 → NP_001259913.1  cytochrome c oxidase subunit 7A-like 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IHY5
      Conserved Domains (1) summary
      cd00928
      Location:3 → 57
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IHY5 Q6IHY5

    Gene LinkOut

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