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    RhoGAP92B Rho GTPase activating protein at 92B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42371, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP92Bprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 92Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038747
    Locus tag
    Dmel_CG4755
    See related
    AllianceGenome:FB:FBgn0038747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4755; Dmel\CG4755; drich; dRich
    Summary
    Enables GTPase activator activity and SH3 domain binding activity. Involved in several processes, including imaginal disc-derived leg morphogenesis; positive regulation of synaptic assembly at neuromuscular junction; and subsynaptic reticulum organization. Located in neuromuscular junction. Is expressed in adult head; organism; pole plasm; primary tracheal branch; and tarsal segment. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to several human genes including ARHGAP17 (Rho GTPase activating protein 17) and SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP92B in Genome Data Viewer
    Location:
    92B6-92B6; 3-67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19905164..19914272)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15730886..15739994)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Caseinolytic protease chaperone subunit Neighboring gene Surfeit 6 Neighboring gene long non-coding RNA:CR45047 Neighboring gene long non-coding RNA:CR45048 Neighboring gene exit protein of rhodopsin and TRP B Neighboring gene exit protein of rhodopsin and TRP A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
    2. Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses. Nath AS, et al. Cell Rep, 2022 Mar 1. PMID 35235794
    3. Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis. Biton T, et al. J Cell Biol, 2023 Nov 6. PMID 37707500, Free PMC Article
    4. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
    5. Feedback inhibition of actin on Rho mediates content release from large secretory vesicles. Segal D, et al. J Cell Biol, 2018 May 7. PMID 29496739, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in subsynaptic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 92B
    Names
    CG4755-PA
    CG4755-PB
    CG4755-PC
    CG4755-PD
    CG4755-PE
    RhoGAP92B-PA
    RhoGAP92B-PB
    RhoGAP92B-PC
    RhoGAP92B-PD
    RhoGAP92B-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19905164..19914272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300488.1 → NP_001287417.1  Rho GTPase activating protein at 92B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T3Q3, Q9VDS5
      UniProtKB/TrEMBL
      B5RIZ2
      Conserved Domains (2) summary
      cd04386
      Location:245 → 452
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
      cl12013
      Location:27 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_142587.3 → NP_650844.1  Rho GTPase activating protein at 92B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T3Q3, Q9VDS5
      UniProtKB/TrEMBL
      B5RIZ2
      Related
      FBpp0083230
      Conserved Domains (2) summary
      cd04386
      Location:245 → 452
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
      cl12013
      Location:27 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001300485.1 → NP_001287414.1  Rho GTPase activating protein at 92B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHC1
      Conserved Domains (2) summary
      cd07595
      Location:27 → 257
      BAR_RhoGAP_Rich-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rich-like Rho GTPase Activating Proteins
      cd04386
      Location:245 → 452
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    4. NM_001300487.1 → NP_001287416.1  Rho GTPase activating protein at 92B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHN0
      Conserved Domains (2) summary
      cd04386
      Location:153 → 360
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
      cl12013
      Location:1 → 165
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. NM_001300486.1 → NP_001287415.1  Rho GTPase activating protein at 92B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHC3
      Conserved Domains (2) summary
      cd04386
      Location:48 → 255
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
      cl12013
      Location:1 → 59
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHC1 A0A0B4LHC1
    A0A0B4LHC3 A0A0B4LHC3
    A0A0B4LHN0 A0A0B4LHN0
    B5RIZ2 B5RIZ2
    Q9VDS5.1 Q9VDS5

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