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    gammaCOP Coat Protein (coatomer) gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43717, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gammaCOPprovided by FlyBase
    Official Full Name
    Coat Protein (coatomer) gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028968
    Locus tag
    Dmel_CG1528
    See related
    AllianceGenome:FB:FBgn0028968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0573/02; 573.02; anon-WO0118547.334; CG1528; copg; COPIgamma; Dmel\CG1528; gamma-cop; gamma-COP; Gamma-COP; gammaCop; l(3)S057302; l(3)S057302b
    Summary
    Predicted to enable structural molecule activity. Involved in several processes, including chitin-based embryonic cuticle biosynthetic process; larval salivary gland morphogenesis; and open tracheal system development. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult brain; adult head; meiotic primary spermatocyte; onion stage spermatid; and primary spermatocyte. Orthologous to human COPG1 (COPI coat complex subunit gamma 1) and COPG2 (COPI coat complex subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gammaCOP in Genome Data Viewer
    Location:
    100C6-100C6; 3-102 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31572143..31575707)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27397865..27401429)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46120 Neighboring gene long non-coding RNA:CR46119 Neighboring gene pygopus Neighboring gene rough deal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion. Kamemura K, et al. Nat Commun, 2024 Oct 10. PMID 39389966, Free PMC Article
    2. Mutations of γCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa. Chifiriuc MC, et al. Int J Mol Sci, 2022 Jun 10. PMID 35742941, Free PMC Article
    3. Effects of Pseudomonas aeruginosa infection on the expression profile of transient receptor potential-like (TRPL) gene from Drosophila melanogaster. Mihalache (Radu) MR, et al. Roum Arch Microbiol Immunol, 2016 Jan-Jun. PMID 29616531
    4. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. Hahn Y, et al. FEBS Lett, 2000 Sep 29. PMID 11018518
    5. gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster. Grieder NC, et al. PLoS One, 2008 Sep 19. PMID 18802472, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster
      Title: gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of tube diameter, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acroblast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coat protein (coatomer) gamma
    Names
    CG1528-PA
    CG1528-PB
    CG1528-PC
    CG1528-PD
    COPI gamma subunit
    gamma-coatomer protein
    gammaCOP-PA
    gammaCOP-PB
    gammaCOP-PC
    gammaCOP-PD
    gammaCop
    lethal (3) S057302b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31572143..31575707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170553.2 → NP_733432.1  coat protein (coatomer) gamma, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733432.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJ29, Q8I0G5, Q8MYW4, Q9U677, Q9V9W9
      UniProtKB/TrEMBL
      G4LU37
      Related
      FBpp0085155
      Conserved Domains (4) summary
      COG5240
      Location:19 → 882
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      pfam08752
      Location:625 → 766
      COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
      pfam16381
      Location:768 → 882
      Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
      sd00044
      Location:407 → 432
      HEAT; HEAT repeat [structural motif]

    2. NM_079869.3 → NP_524608.1  coat protein (coatomer) gamma, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU37
      Related
      FBpp0085154
      Conserved Domains (4) summary
      COG5240
      Location:3 → 878
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      pfam08752
      Location:621 → 762
      COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
      pfam16381
      Location:764 → 878
      Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
      sd00044
      Location:403 → 428
      HEAT; HEAT repeat [structural motif]

    3. NM_001170313.1 → NP_001163784.1  coat protein (coatomer) gamma, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU37
      Conserved Domains (4) summary
      COG5240
      Location:11 → 877
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      pfam08752
      Location:620 → 761
      COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
      pfam16381
      Location:763 → 877
      Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
      sd00044
      Location:402 → 427
      HEAT; HEAT repeat [structural motif]

    4. NM_001276216.1 → NP_001263145.1  coat protein (coatomer) gamma, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHL2, G4LU37
      Conserved Domains (4) summary
      COG5240
      Location:11 → 877
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      pfam08752
      Location:620 → 761
      COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
      pfam16381
      Location:763 → 877
      Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
      sd00044
      Location:402 → 427
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHL2 A0A0B4KHL2
    Q2VA12 Q2VA12
    Q8I0G5.1 Q8I0G5

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