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    Dnah3 dynein, axonemal, heavy chain 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38586, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dnah3provided by FlyBase
    Official Full Name
    dynein, axonemal, heavy chain 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0035581
    Locus tag
    Dmel_CG17150
    See related
    AllianceGenome:FB:FBgn0035581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17150; DHC64C; DHC7B; Dmel\CG17150
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility; response to auditory stimulus; and sperm competition. Is active in sperm flagellum. Is expressed in antenna; chordotonal neurons; femoral chordotonal organ; male germline cell; and testis. Orthologous to human DNAH3 (dynein axonemal heavy chain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dnah3 in Genome Data Viewer
    Location:
    64C1-64C2; 3-13 cM
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4861269..4895749)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4861269..4895749)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hoka

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A "mesmer"izing new approach to site-directed mutagenesis in large transformation-ready constructs: Mutagenesis via Serial Small Mismatch Recombineering. Jacobs JS, et al. Fly (Austin), 2011 Apr-Jun. PMID 21339708, Free PMC Article
    2. The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly. Zur Lage P, et al. Biol Open, 2021 Oct 15. PMID 34553759, Free PMC Article
    3. The genetic architecture of larval aggregation behavior in Drosophila. McKinney RM, et al. J Neurogenet, 2021 Sep. PMID 33629904
    4. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
    5. A Cyclin E Centered Genetic Network Contributes to Alcohol-Induced Variation in Drosophila Development. Morozova TV, et al. G3 (Bethesda), 2018 Jul 31. PMID 29871898, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm competition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein, axonemal, heavy chain 3
    Names
    CG17150-PD
    CG17150-PE
    Dnah3-PD
    Dnah3-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4861269..4895749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139680.3 → NP_647937.2  dynein, axonemal, heavy chain 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647937.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ77
      Conserved Domains (5) summary
      pfam03028
      Location:3659 → 4373
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:1086 → 1489
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2929 → 3272
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3304 → 3519
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1620 → 1847
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001144413.2 → NP_001137885.1  dynein, axonemal, heavy chain 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1LZ38
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LZ38 Q1LZ38
    Q9VZ77 Q9VZ77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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