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    Naus Nausicaa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nausprovided by FlyBase
    Official Full Name
    Nausicaaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034308
    Locus tag
    Dmel_CG10915
    See related
    AllianceGenome:FB:FBgn0034308
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10915; Dmel\CG10915; naus
    Summary
    Involved in actin filament bundle retrograde transport; positive regulation of cellular component organization; and protein localization to actin cytoskeleton. Located in lamellipodium and stress fiber. Part of FAR/SIN/STRIPAK complex. Is expressed in embryonic brain and organism. Orthologous to several human genes including CTTNBP2NL (CTTNBP2 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naus in Genome Data Viewer
    Location:
    55B9-55B10; 2-84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18160720..18164746)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14048225..14052251)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lola like Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 75kD Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 9 Neighboring gene Dgp-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner. O'Connell ME, et al. Biol Open, 2019 Jun 17. PMID 31164339, Free PMC Article
    2. A conserved STRIPAK complex is required for autophagy in muscle tissue. Guo Y, et al. Mol Biol Cell, 2023 Aug 1. PMID 37379167, Free PMC Article
    3. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Ribeiro PS, et al. Mol Cell, 2010 Aug 27. PMID 20797625
    4. Large-scale analysis of Drosophila core promoter function using synthetic promoters. Qi Z, et al. Mol Syst Biol, 2022 Feb. PMID 35156763, Free PMC Article
    5. Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division. Daeden A, et al. Nat Cell Biol, 2023 Feb. PMID 36747081, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actin filament bundle retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nausicaa
    Names
    CG10915-PA
    CG10915-PB
    Naus-PA
    Naus-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18160720..18164746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299636.1 → NP_001286565.1  nausicaa, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LFS3, Q8SX68, Q9V8D0
      Conserved Domains (2) summary
      pfam09727
      Location:78 → 274
      CortBP2; Cortactin-binding protein-2
      pfam12240
      Location:189 → 381
      Angiomotin_C; Angiomotin C terminal

    2. NM_137455.5 → NP_611299.2  nausicaa, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LFS3, Q8SX68, Q9V8D0
      Related
      FBpp0085925
      Conserved Domains (2) summary
      pfam09727
      Location:78 → 274
      CortBP2; Cortactin-binding protein-2
      pfam12240
      Location:189 → 381
      Angiomotin_C; Angiomotin C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX68.1 Q8SX68

    Gene LinkOut

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