U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    bdl borderless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33635, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bdlprovided by FlyBase
    Official Full Name
    borderlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028482
    Locus tag
    Dmel_CG16857
    See related
    AllianceGenome:FB:FBgn0028482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH11322; CG16857; CT35491; Dmel\CG16857; GH11322
    Summary
    Enables cell-cell adhesion mediator activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; nervous system development; and neuron cell-cell adhesion. Located in plasma membrane. Is expressed in several structures, including adult head; adult optic lobe; glial cell; medulla layer; and synaptic neuropil domain. Orthologous to human IGSF9 (immunoglobulin superfamily member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See bdl in Genome Data Viewer
    Location:
    24E1-24E1; 2-12 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4324554..4331830)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4324554..4331830)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Arginine methyltransferase 2 Neighboring gene turtle Neighboring gene ABC transporter expressed in trachea Neighboring gene long non-coding RNA:CR44697 Neighboring gene mir-1005 stem loop

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Turtle interacts with borderless in regulating glial extension and axon ensheathment. Chen Y, et al. Mol Brain, 2017 May 23. PMID 28535795, Free PMC Article
    2. The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision in Drosophila. Shaw HS, et al. J Neurosci, 2019 Aug 28. PMID 31235647, Free PMC Article
    3. Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila. Chang YC, et al. Sci Rep, 2018 Aug 23. PMID 30140062, Free PMC Article
    4. Borderless regulates glial extension and axon ensheathment. Cameron S, et al. Dev Biol, 2016 Jun 15. PMID 27131624
    5. Control of directional change after mechanical stimulation in Drosophila. Zhou Y, et al. Mol Brain, 2012 Oct 29. PMID 23107101, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. bdl plays a novel and specific role in regulating axonal transport of SV components. Loss of bdl disrupts axonal transport of SV components in photoreceptor R8 axons, but does not affect the transport of mitochondria. Genetic mosaic analysis, transgene rescue and cell-type-specific knockdown indicate that Bdl is required both presynaptically and postsynaptically for delivering SV components in R8 axons
      Title: The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision in Drosophila.
    2. Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment.
      Title: Turtle interacts with borderless in regulating glial extension and axon ensheathment.
    3. Bdl is expressed in wrapping glia (WG) in the developing eye disc. Bdl is specifically required in WG for the extension of glial processes along photoreceptor axons in the optic lobe, and axon ensheathment.
      Title: Borderless regulates glial extension and axon ensheathment.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell-cell adhesion mediator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glial cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    borderless
    Names
    CG16857-PA
    bdl-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4324554..4331830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134978.3 → NP_608822.1  borderless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608822.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0PTX2, Q95U86, Q9U4G1, Q9VQY3
      Related
      FBpp0077115
      Conserved Domains (6) summary
      smart00408
      Location:356 → 419
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:435 → 524
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:153 → 242
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:252 → 337
      Ig_2; Immunoglobulin domain
      cl11960
      Location:157 → 242
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U4G1.1 Q9U4G1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools