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    Cenpi centromere protein I [ Mus musculus (house mouse) ]

    Gene ID: 102920, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cenpiprovided by MGI
    Official Full Name
    centromere protein Iprovided by MGI
    Primary source
    MGI:MGI:2147897
    See related
    Ensembl:ENSMUSG00000031262 AllianceGenome:MGI:2147897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CENP-I; Fshprh1
    Summary
    This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in liver E14 (RPKM 5.1), liver E14.5 (RPKM 4.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpi in Genome Data Viewer
    Location:
    X E3; X 56.08 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133206777..133263853)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134308084..134363104)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47955 Neighboring gene TRM2 tRNA methyltransferase 2B Neighboring gene transmembrane protein 35A Neighboring gene STARR-seq mESC enhancer starr_47958 Neighboring gene STARR-seq mESC enhancer starr_47959 Neighboring gene dystrophin related protein 2 Neighboring gene TATA-box binding protein associated factor 7 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40943

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in centromere complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of inner kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein I
    Names
    FSH primary response protein 1
    follicle-stimulating hormone primary response protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305631.1 → NP_001292560.1  centromere protein I

      See identical proteins and their annotated locations for NP_001292560.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK043344, AK085048, AK161473
      Consensus CDS
      CCDS30393.1
      UniProtKB/Swiss-Prot
      Q8BXU9, Q8K1K4
      UniProtKB/TrEMBL
      Q3TTB0, Q3UM07
      Related
      ENSMUSP00000098809.2, ENSMUST00000101251.8
      Conserved Domains (1) summary
      pfam07778
      Location:12 → 516
      CENP-I; Mis6

    2. NM_145924.3 → NP_666036.1  centromere protein I

      See identical proteins and their annotated locations for NP_666036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK043344, AK085048, AK161473
      Consensus CDS
      CCDS30393.1
      UniProtKB/Swiss-Prot
      Q8BXU9, Q8K1K4
      UniProtKB/TrEMBL
      Q3TTB0, Q3UM07
      Related
      ENSMUSP00000079851.6, ENSMUST00000081064.12
      Conserved Domains (1) summary
      pfam07778
      Location:12 → 516
      CENP-I; Mis6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133206777..133263853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528477.3 → XP_006528540.1  centromere protein I isoform X2

      Conserved Domains (1) summary
      pfam07778
      Location:12 → 463
      CENP-I; Mis6

    2. XM_017318340.2 → XP_017173829.1  centromere protein I isoform X1

      UniProtKB/Swiss-Prot
      Q8BXU9, Q8K1K4
      UniProtKB/TrEMBL
      Q3TTB0, Q3UM07
      Conserved Domains (1) summary
      pfam07778
      Location:12 → 516
      CENP-I; Mis6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1K4.1 GenPept UniProtKB/Swiss-Prot:Q8K1K4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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