Kctd12 potassium channel tetramerisation domain containing 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd12provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 12provided by MGI
Primary source: MGI:MGI:2145823
See related: Ensembl:ENSMUSG00000098557 AllianceGenome:MGI:2145823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pfet1; Pfetin
Summary: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Part of receptor complex. Is active in GABA-ergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and inner ear. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 14 E2.3; 14 51.55 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (103214017..103220073, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (102976581..102982637, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCTD8 and KCTD12 Facilitate Axonal Expression of GABAB Receptors in Habenula Cholinergic Neurons.
Title: KCTD8 and KCTD12 Facilitate Axonal Expression of GABA(B) Receptors in Habenula Cholinergic Neurons.
The effects of Kctd12, an auxiliary subunit of GABAB receptor in dentate gyrus on behavioral response to chronic social defeat stress in mice.
Title: The effects of Kctd12, an auxiliary subunit of GABA(B) receptor in dentate gyrus on behavioral response to chronic social defeat stress in mice.
KCTD12 is involved in determining phenotypes of emotionality, behavioral activity and neuronal excitability.
Title: Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders.
Serine-892 phosphorylation in GABAB receptor rearranges KCTD12 at the receptor and slows KCTD12-induced desensitization in neurons.
Title: GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization.
the up-regulation of functional GABA(B) receptors at the neuronal plasma membrane is an additional physiological role of the auxiliary subunit KCTD12.
Title: Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).
Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
Title: Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.
new gene encoding 327 amino acids in mouse contains a voltage-gated potassium (K+) channel tetramerization (T1) domain.
Title: Isolation from cochlea of a novel human intronless gene with predominant fetal expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kctd12 (e-PCR), detects polymorphism
- UniSTS:506678

Kctd12 (e-PCR), detects polymorphism
- UniSTS:506679

Kctd12 (e-PCR), detects polymorphism
- UniSTS:506680

AU046135 (e-PCR)
- UniSTS:160421

AW538430 (e-PCR)
- UniSTS:180714

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD12

Names: potassium channel tetramerization domain containing 12; predominantly fetal expressed T1 domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177715.4 → NP_808383.3 BTB/POZ domain-containing protein KCTD12

Status: VALIDATED

Source sequence(s)

AK087895, AK173260, BP753689, CF538046

Consensus CDS

CCDS70611.1

UniProtKB/Swiss-Prot

Q3T9E3, Q6WVG3

UniProtKB/TrEMBL

A0A0R4J2B2

Related

ENSMUSP00000139261.2, ENSMUST00000184744.2

Conserved Domains (1) summary

cl02518
Location:36 → 125

BTB; BTB/POZ domain