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    Pccb propionyl Coenzyme A carboxylase, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 66904, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pccbprovided by MGI
    Official Full Name
    propionyl Coenzyme A carboxylase, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:1914154
    See related
    Ensembl:ENSMUSG00000032527 AllianceGenome:MGI:1914154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300012P06Rik
    Summary
    Predicted to enable propionyl-CoA carboxylase activity. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and respiratory system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCB (propionyl-CoA carboxylase subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 119.2), liver adult (RPKM 65.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pccb in Genome Data Viewer
    Location:
    9 E4; 9 53.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100864085..100916993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (100982032..101034940, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STAG1 cohesin complex component Neighboring gene STARR-positive B cell enhancer ABC_E6797 Neighboring gene predicted gene 8661 Neighboring gene adaptor-related protein complex 2, beta 1 subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_25043 Neighboring gene RIKEN cDNA 6720484G13 gene Neighboring gene STARR-positive B cell enhancer ABC_E11420 Neighboring gene STARR-positive B cell enhancer ABC_E2300 Neighboring gene STARR-seq mESC enhancer starr_25045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:100965416-100965626 Neighboring gene STARR-seq mESC enhancer starr_25047 Neighboring gene brain expressed X-linked 2 pseudogene Neighboring gene predicted gene, 46140

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, mapping and expression of the mouse propionyl CoA carboxylase beta (pccb), the gene for human type II propionic acidaemia. Schrick JJ, et al. Gene, 2001 Feb 7. PMID 11245989
    2. Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice. Huang S, et al. Circulation, 2019 Jun 18. PMID 30947518, Free PMC Article
    3. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. Fan X, et al. Elife, 2021 Feb 8. PMID 33554859, Free PMC Article
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    5. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables propionyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables propionyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables propionyl-CoA carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    propionyl-CoA carboxylase beta chain, mitochondrial
    Names
    PCCase subunit beta
    propanoyl-CoA:carbon dioxide ligase subunit beta
    NP_001298078.1
    NP_080111.1
    XP_006511433.1
    XP_036011089.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311149.1 → NP_001298078.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC134825, AK050366, AK134437, BM948065, CF948895, CO043598
      Consensus CDS
      CCDS81063.1
      UniProtKB/TrEMBL
      E9Q1J7, Q3UYS0
      Related
      ENSMUSP00000118006.2, ENSMUST00000149322.8
      Conserved Domains (2) summary
      COG4799
      Location:39 → 504
      MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]
      cl23717
      Location:65 → 181
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_025835.3 → NP_080111.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_080111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC134825, AK004976, AK050366
      Consensus CDS
      CCDS23442.1
      UniProtKB/Swiss-Prot
      Q99MN9, Q9DBG2
      UniProtKB/TrEMBL
      Q7TMF4
      Related
      ENSMUSP00000035116.5, ENSMUST00000035116.12
      Conserved Domains (2) summary
      COG4799
      Location:39 → 541
      MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]
      cl23717
      Location:65 → 212
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      100864085..100916993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155196.1 → XP_036011089.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q3UYS0
      Conserved Domains (1) summary
      pfam01039
      Location:62 → 462
      Carboxyl_trans; Carboxyl transferase domain

    2. XM_006511370.2 → XP_006511433.1  propionyl-CoA carboxylase beta chain, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q7TMF4
      Conserved Domains (1) summary
      pfam01039
      Location:62 → 499
      Carboxyl_trans; Carboxyl transferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MN9.2 GenPept UniProtKB/Swiss-Prot:Q99MN9

    Gene LinkOut

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