Ube2t ubiquitin-conjugating enzyme E2T [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2tprovided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2Tprovided by MGI
Primary source: MGI:MGI:1914446
See related: Ensembl:ENSMUSG00000026429 AllianceGenome:MGI:1914446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700084L22Rik
Summary: Predicted to enable chromatin binding activity; ubiquitin conjugating enzyme activity; and ubiquitin protein ligase binding activity. Predicted to be involved in DNA repair and protein ubiquitination. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; limb bud; nasal cavity epithelium; and thymus primordium. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group T. Orthologous to human UBE2T (ubiquitin conjugating enzyme E2 T). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 20.3), liver E14 (RPKM 12.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.24 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134890303..134901918)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134962565..134974180)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/beta-Catenin Signaling Pathway.
Title: UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/β-Catenin Signaling Pathway.
UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells.
Title: UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells.
UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.
Title: UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.
Overexpression of UBE2T in NIH3T3 cells significantly promoted colony formation in mouse cell cultures.
Title: Elevated expression of UBE2T in lung cancer tumors and cell lines.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K27-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K29-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 T

Names: E2 ubiquitin-conjugating enzyme T; ubiquitin carrier protein T; ubiquitin-conjugating enzyme E2T (putative); ubiquitin-protein ligase T

NP_001265044.1

EC 2.3.2.23

NP_080300.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278115.1 → NP_001265044.1 ubiquitin-conjugating enzyme E2 T

See identical proteins and their annotated locations for NP_001265044.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK012565, BB872310, BY576015, CK334733

Consensus CDS

CCDS15313.1

UniProtKB/Swiss-Prot

Q9CQ37

Conserved Domains (2) summary

COG5078
Location:1 → 151

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00195
Location:5 → 147

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_026024.3 → NP_080300.1 ubiquitin-conjugating enzyme E2 T

See identical proteins and their annotated locations for NP_080300.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK012565, BB872310, BY576015

Consensus CDS

CCDS15313.1

UniProtKB/Swiss-Prot

Q9CQ37

Related

ENSMUSP00000027687.8, ENSMUST00000027687.8

Conserved Domains (2) summary

COG5078
Location:1 → 151

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00195
Location:5 → 147

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...