Klhl22 kelch-like 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhl22provided by MGI
Official Full Name: kelch-like 22provided by MGI
Primary source: MGI:MGI:1337995
See related: Ensembl:ENSMUSG00000022750 AllianceGenome:MGI:1337995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kelchl; 2610318I18Rik
Summary: Predicted to enable 14-3-3 protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including centrosome; intercellular bridge; and intracellular membrane-bounded organelle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol; mitotic spindle; and polar microtubule. Predicted to colocalize with lysosome and nucleus. Orthologous to human KLHL22 (kelch like family member 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 28.6), ovary adult (RPKM 22.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.01 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17577485..17611246)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17759621..17793382)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
Title: Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI746539 (e-PCR)
- UniSTS:165980

NoName (e-PCR)
- UniSTS:237452

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	ISO Inferred from Sequence Orthology more info
involved_in cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-leucine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell mediated immune response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
colocalizes_with lysosome	ISO Inferred from Sequence Orthology more info
colocalizes_with lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with nucleus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nucleus	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in polar microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in polar microtubule	ISO Inferred from Sequence Orthology more info
located_in polar microtubule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kelch-like protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359068.1 → NP_001345997.1 kelch-like protein 22 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC087802

Consensus CDS

CCDS49783.1

UniProtKB/Swiss-Prot

D3YW27, Q8BT13, Q99JN2

Related

ENSMUSP00000112412.2, ENSMUST00000120488.3

Conserved Domains (4) summary

PHA03098
Location:52 → 592

PHA03098; kelch-like protein; Provisional

sd00038
Location:340 → 385

Kelch; KELCH repeat [structural motif]

cd18251
Location:27 → 151

BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
NM_001379022.1 → NP_001365951.1 kelch-like protein 22 isoform 1

Status: VALIDATED

Source sequence(s)

AC087802

UniProtKB/Swiss-Prot

D3YW27, Q8BT13, Q99JN2

Conserved Domains (4) summary

PHA03098
Location:52 → 592

PHA03098; kelch-like protein; Provisional

sd00038
Location:340 → 385

Kelch; KELCH repeat [structural motif]

cd18251
Location:27 → 151

BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
NM_001379023.1 → NP_001365952.1 kelch-like protein 22 isoform 1

Status: VALIDATED

Source sequence(s)

AC087802

UniProtKB/Swiss-Prot

D3YW27, Q8BT13, Q99JN2

Conserved Domains (4) summary

PHA03098
Location:52 → 592

PHA03098; kelch-like protein; Provisional

sd00038
Location:340 → 385

Kelch; KELCH repeat [structural motif]

cd18251
Location:27 → 151

BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
NM_001379024.1 → NP_001365953.1 kelch-like protein 22 isoform 2

Status: VALIDATED

Source sequence(s)

AC087802

Conserved Domains (4) summary

PHA03098
Location:71 → 611

PHA03098; kelch-like protein; Provisional

sd00038
Location:359 → 404

Kelch; KELCH repeat [structural motif]

cd18251
Location:46 → 170

BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)

cd18461
Location:166 → 269

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
NM_001379025.1 → NP_001365954.1 kelch-like protein 22 isoform 3

Status: VALIDATED

Source sequence(s)

AC087802, AK030669

UniProtKB/TrEMBL

Q8CDC1

Conserved Domains (3) summary

sd00038
Location:294 → 335

Kelch; KELCH repeat [structural motif]

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

cl38908
Location:27 → 151

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_001379026.1 → NP_001365955.1 kelch-like protein 22 isoform 3

Status: VALIDATED

Source sequence(s)

AC087802

UniProtKB/TrEMBL

Q8CDC1

Conserved Domains (3) summary

sd00038
Location:294 → 335

Kelch; KELCH repeat [structural motif]

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

cl38908
Location:27 → 151

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_145479.4 → NP_663454.3 kelch-like protein 22 isoform 1

See identical proteins and their annotated locations for NP_663454.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI845204, AK143514, CJ159851

Consensus CDS

CCDS49783.1

UniProtKB/Swiss-Prot

D3YW27, Q8BT13, Q99JN2

Related

ENSMUSP00000127227.2, ENSMUST00000165790.9

Conserved Domains (4) summary

PHA03098
Location:52 → 592

PHA03098; kelch-like protein; Provisional

sd00038
Location:340 → 385

Kelch; KELCH repeat [structural motif]

cd18251
Location:27 → 151

BTB_POZ_KLHL22; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22)

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)