Plcd3 phospholipase C, delta 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plcd3provided by MGI
Official Full Name: phospholipase C, delta 3provided by MGI
Primary source: MGI:MGI:107451
See related: Ensembl:ENSMUSG00000020937 AllianceGenome:MGI:107451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1964; 2610205J15Rik
Summary: Predicted to enable phosphatidylinositol phospholipase C activity. Acts upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 8.4), stomach adult (RPKM 7.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.71 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102960062..102992484, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103070296..103101710, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
Title: Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface.
Title: Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
These results indicate that PLCdelta3 could participate in stability of microvilli structure via regulating and anchoring of Myo6 to plasma membrane.
Title: Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane.
PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension.
Title: Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.
double disruption of PLCd1 and PLCd3 results in embryonic lethality because of insufficient vasculariztion of the placenta.
Title: Physiological functions of phospholipase C delta-type.
PLCdelta1 and PLCdelta3 are essential in trophoblasts for placental development.
Title: Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plcd3 (e-PCR), detects polymorphism
- UniSTS:507154

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Plcd3 (e-PCR), detects polymorphism
- UniSTS:546952

NoName (e-PCR)
- UniSTS:236752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Names: PLC-delta-3; phosphoinositide phospholipase C-delta-3

NP_001348635.1

EC 3.1.4.11

NP_690026.2

EC 3.1.4.11

XP_006534371.1

EC 3.1.4.11

XP_006534372.1

EC 3.1.4.11

XP_017170277.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361706.1 → NP_001348635.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL731805

Conserved Domains (4) summary

cd08630
Location:272 → 567

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

cd13363
Location:1 → 117

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam14788
Location:137 → 186

EF-hand_10; EF hand

cl27705
Location:191 → 718

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
NM_152813.3 → NP_690026.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 1

See identical proteins and their annotated locations for NP_690026.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK011892, AK046669, AL731805, BY011789, BY589869

Consensus CDS

CCDS25512.1

UniProtKB/Swiss-Prot

A2AHR0, A2AHR1, Q3UME8, Q69Z55, Q8BL19, Q8K2J0

Related

ENSMUSP00000099366.2, ENSMUST00000103077.2

Conserved Domains (7) summary

cd00275
Location:656 → 783

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08630
Location:332 → 627

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

PLN02228
Location:251 → 778

PLN02228; Phosphoinositide phospholipase C

cd13363
Location:61 → 177

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:66 → 163

PH; PH domain

pfam09279
Location:251 → 332

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam14788
Location:197 → 246

EF-hand_10; EF hand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

102960062..102992484 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534308.4 → XP_006534371.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

Conserved Domains (4) summary

PLN02228
Location:251 → 777

PLN02228; Phosphoinositide phospholipase C

cd13363
Location:61 → 177

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam14788
Location:197 → 246

EF-hand_10; EF hand

cl14615
Location:332 → 626

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
XM_006534309.5 → XP_006534372.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

Conserved Domains (4) summary

cd08630
Location:291 → 586

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

PLN02228
Location:210 → 737

PLN02228; Phosphoinositide phospholipase C

cd13363
Location:20 → 136

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam14788
Location:156 → 205

EF-hand_10; EF hand
XM_017314788.3 → XP_017170277.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

UniProtKB/TrEMBL

F7AAE0

Related

ENSMUSP00000117455.2, ENSMUST00000128650.8

Conserved Domains (2) summary

cd00275
Location:343 → 470

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cl14615
Location:20 → 314

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily