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Gata3 GATA binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 14462, updated on 27-Nov-2024

Summary

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Official Symbol: Gata3provided by MGI
Official Full Name: GATA binding protein 3provided by MGI
Primary source: MGI:MGI:95663
See related: Ensembl:ENSMUSG00000015619 AllianceGenome:MGI:95663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: jal; Gata-3
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; interleukin-2 receptor binding activity; and transcription coactivator binding activity. Involved in several processes, including epithelial tube formation; heart development; and intracellular signal transduction. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and ureter development. Located in nucleus. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study hypoparathyroidism-deafness-renal disease syndrome. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 23.1), mammary gland adult (RPKM 22.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

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See Gata3 in Genome Data Viewer

Location:: 2 A1; 2 6.69 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (9861889..9894845, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (9857078..9887953, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling.
Title: Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling.
Stage-specific GATA3 induction promotes ILC2 development after lineage commitment.
Title: Stage-specific GATA3 induction promotes ILC2 development after lineage commitment.
Effect of ADSCs on Th17/Treg and T-bet/GATA-3 in model mice with primary immune thrombocytopenia.
Title: Effect of ADSCs on Th17/Treg and T-bet/GATA-3 in model mice with primary immune thrombocytopenia.
GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer.
Title: GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer.
GATA3 promotes the autophagy and activation of hepatic stellate cell in hepatic fibrosis via regulating miR-370/HMGB1 pathway.
Title: GATA3 promotes the autophagy and activation of hepatic stellate cell in hepatic fibrosis via regulating miR-370/HMGB1 pathway.
Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.
Title: Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.
m[6]A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner.
Title: m(6)A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner.
Gata3 is required in late proneurosensory development for proper sensory cell formation and organization.
Title: Gata3 is required in late proneurosensory development for proper sensory cell formation and organization.
[Changes in percentage of GATA3[+] regulatory T cells and their pathogenic roles in allergic rhinitis].
Title: [Changes in percentage of GATA3(+) regulatory T cells and their pathogenic roles in allergic rhinitis].
GATA3 mediates nonclassical beta-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis.
Title: GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (223)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Spontaneous (1)
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GATA3 (e-PCR)
- UniSTS:506387

NoName (e-PCR)
- UniSTS:548372

Gata3 (e-PCR), detects polymorphism
- UniSTS:506928

Gata3 (e-PCR), detects polymorphism
- UniSTS:463943

Gata3 (e-PCR), detects polymorphism
- UniSTS:461918

PMC186616P1 (e-PCR)
- UniSTS:271712

Gata3 (e-PCR), detects polymorphism
- UniSTS:463209

Gata3 (e-PCR), detects polymorphism
- UniSTS:498319

X55123 (e-PCR)
- UniSTS:158919

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables HMG box domain binding	IEA Inferred from Electronic Annotation more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone methyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-2 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac right ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate determination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to BMP stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-alpha	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-4	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ear development	ISO Inferred from Sequence Orthology more info
involved_in ear development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte migration	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mast cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesonephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell motility	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell proliferation involved in mesonephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephric duct formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephric duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within norepinephrine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within parathyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within parathyroid hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thyroid hormone generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ureteric bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pro-T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T-helper cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to X-ray	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of establishment of cell polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nephron tubule epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type IV hypersensitivity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureter maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureter morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ureteric bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: trans-acting T-cell-specific transcription factor GATA-3

Names: GATA-binding factor 3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355110.2 → NP_001342039.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 2

Status: VALIDATED

Source sequence(s)

AL845529

UniProtKB/TrEMBL

Q3U223

Conserved Domains (2) summary

cd00202
Location:315 → 365

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cl25836
Location:72 → 275

Retinal; Retinal protein
NM_001355111.2 → NP_001342040.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 3

Status: VALIDATED

Source sequence(s)

AL845529

UniProtKB/TrEMBL

Q3TZD6

Conserved Domains (3) summary

smart00401
Location:312 → 350

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:262 → 312

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cl25836
Location:72 → 276

Retinal; Retinal protein
NM_001355112.2 → NP_001342041.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 4

Status: VALIDATED

Source sequence(s)

AL845529

UniProtKB/TrEMBL

Q3TZD6

Conserved Domains (3) summary

smart00401
Location:311 → 349

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:261 → 311

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cl25836
Location:72 → 275

Retinal; Retinal protein
NM_001417046.1 → NP_001403975.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

Status: VALIDATED

Source sequence(s)

AL845529

UniProtKB/Swiss-Prot

P23772

UniProtKB/TrEMBL

Q3U0R5
NM_001417048.1 → NP_001403977.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

Status: VALIDATED

Source sequence(s)

AL845529

UniProtKB/Swiss-Prot

P23772

UniProtKB/TrEMBL

Q3U0R5
NM_001417049.1 → NP_001403978.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

Status: VALIDATED

Source sequence(s)

AL845529, AL928704

UniProtKB/Swiss-Prot

P23772

UniProtKB/TrEMBL

Q3U0R5
NM_001417050.1 → NP_001403979.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

Status: VALIDATED

Source sequence(s)

AL845529, AL928704

UniProtKB/Swiss-Prot

P23772

UniProtKB/TrEMBL

Q3U0R5
NM_001417051.1 → NP_001403980.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

Status: VALIDATED

Source sequence(s)

AL845529, AL928704

UniProtKB/Swiss-Prot

P23772

UniProtKB/TrEMBL

Q3U0R5
NM_001417052.1 → NP_001403981.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 2

Status: VALIDATED

Source sequence(s)

AL845529, AL928704
NM_001417053.1 → NP_001403982.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 3

Status: VALIDATED

Source sequence(s)

AL845529, AL928704
NM_001417054.1 → NP_001403983.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 3

Status: VALIDATED

Source sequence(s)

AL845529, AL928704
NM_008091.4 → NP_032117.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

See identical proteins and their annotated locations for NP_032117.1

Status: VALIDATED

Source sequence(s)

AL845529

Consensus CDS

CCDS15674.1

UniProtKB/Swiss-Prot

P23772

UniProtKB/TrEMBL

Q3U0R5, Q3U223

Related

ENSMUSP00000100041.4, ENSMUST00000102976.4

Conserved Domains (2) summary

PHA03377
Location:76 → 260

PHA03377; EBNA-3C; Provisional

cd00202
Location:316 → 366

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C