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    Ngrn neugrin, neurite outgrowth associated [ Mus musculus (house mouse) ]

    Gene ID: 83485, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ngrnprovided by MGI
    Official Full Name
    neugrin, neurite outgrowth associatedprovided by MGI
    Primary source
    MGI:MGI:1933212
    See related
    Ensembl:ENSMUSG00000047084 AllianceGenome:MGI:1933212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Located in nucleus. Is expressed in several structures, including brain; heart; liver; metanephros; and spinal cord ventral horn. Orthologous to human NGRN (neugrin, neurite outgrowth associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 19.2), CNS E18 (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ngrn in Genome Data Viewer
    Location:
    7 D2; 7 45.58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79910963..79915126)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80261215..80265378)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4940 Neighboring gene tubulin tyrosine ligase-like family, member 13 Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene vacuolar protein sorting 33B Neighboring gene STARR-positive B cell enhancer ABC_E2827 Neighboring gene RCC1 domain containing 1 Neighboring gene protein regulator of cytokinesis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. Ishigaki S, et al. Biochem Biophys Res Commun, 2000 Dec 20. PMID 11118320
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial ribosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neugrin
    Names
    FI58Gm
    m-Neugrin
    neurite outgrowth-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031375.4 → NP_113552.3  neugrin precursor

      See identical proteins and their annotated locations for NP_113552.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the functional protein.
      Source sequence(s)
      AC109232, AI506588, AK083330, CJ154012
      Consensus CDS
      CCDS21393.2
      UniProtKB/Swiss-Prot
      Q8C401, Q99KS2, Q99PU9
      Related
      ENSMUSP00000113444.2, ENSMUST00000117989.2
      Conserved Domains (1) summary
      pfam06413
      Location:73 → 293
      Neugrin; Neugrin

    RNA

    1. NR_028053.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) retains an intron in the 5' coding region, compared to variant 2. This variant is represented as non-coding because translation would be expected to begin at the 5'-most translation start codon, as used in variant 1, which has a strong Kozak signal. However, translation from this start site renders the transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not clear which, if any, protein may be expressed from this variant.
      Source sequence(s)
      AC109232, AI506588, AK083330
      Related
      ENSMUST00000138005.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79910963..79915126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KS2.3 GenPept UniProtKB/Swiss-Prot:Q99KS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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