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    Pramel12 PRAME like 12 [ Mus musculus (house mouse) ]

    Gene ID: 242736, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pramel12provided by MGI
    Official Full Name
    PRAME like 12provided by MGI
    Primary source
    MGI:MGI:2140473
    See related
    Ensembl:ENSMUSG00000046862 AllianceGenome:MGI:2140473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pramef8; 4732496O08Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF7 (PRAME family member 7) and PRAMEF8 (PRAME family member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.7), limb E14.5 (RPKM 3.2) and 28 other tissues See more
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    Genomic context

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    See Pramel12 in Genome Data Viewer
    Location:
    4 E1; 4 77.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (143137457..143147661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143412155..143421091)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1 Neighboring gene PRAME like 1 Neighboring gene STARR-seq mESC enhancer starr_11972 Neighboring gene oogenesin 4 Neighboring gene KH-type splicing regulatory protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PRAME family member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355724.1 → NP_001342653.1  PRAME family member 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029142, BC056931, BQ745938
      Consensus CDS
      CCDS38944.1
      UniProtKB/TrEMBL
      Q8CE24
      Related
      ENSMUSP00000041323.8, ENSMUST00000037356.8
      Conserved Domains (2) summary
      sd00033
      Location:251 → 271
      LRR_RI; leucine-rich repeat [structural motif]
      cl12013
      Location:238 → 338
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_172877.3 → NP_766465.1  PRAME family member 8

      See identical proteins and their annotated locations for NP_766465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029142, BC056931
      Consensus CDS
      CCDS38944.1
      UniProtKB/TrEMBL
      Q8CE24
      Related
      ENSMUSP00000058676.4, ENSMUST00000059790.11
      Conserved Domains (2) summary
      sd00033
      Location:251 → 271
      LRR_RI; leucine-rich repeat [structural motif]
      cl12013
      Location:238 → 338
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      143137457..143147661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538857.5 → XP_006538920.1  PRAME family member 8 isoform X1

      See identical proteins and their annotated locations for XP_006538920.1

      UniProtKB/TrEMBL
      Q8CE24
      Conserved Domains (2) summary
      sd00033
      Location:251 → 271
      LRR_RI; leucine-rich repeat [structural motif]
      cl12013
      Location:238 → 338
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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