Dclre1b DNA cross-link repair 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dclre1bprovided by MGI
Official Full Name: DNA cross-link repair 1Bprovided by MGI
Primary source: MGI:MGI:2156057
See related: Ensembl:ENSMUSG00000027845 AllianceGenome:MGI:2156057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SNMIB; Apollo; mSNM1B
Summary: Enables 5'-3' exonuclease activity. Involved in protection from non-homologous end joining at telomere; telomeric 3' overhang formation; and telomeric loop formation. Located in chromosome, telomeric region. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 4.1), liver E14 (RPKM 3.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.52 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (103707921..103716703, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (103800605..103809387, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development
Title: The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion.
Title: Apollo contributes to G overhang maintenance and protects leading-end telomeres.
Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
Title: SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dclre1b (e-PCR), detects polymorphism
- UniSTS:479094

AI452214 (e-PCR)
- UniSTS:178908

NoName (e-PCR)
- UniSTS:492528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-3' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' exonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 5'-3' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables beta-lactamase activity	ISO Inferred from Sequence Orthology more info
enables beta-lactamase activity	ISS Inferred from Sequence or Structural Similarity more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide-excision repair	ISA Inferred from Sequence Alignment more info	PubMed
involved_in protection from non-homologous end joining at telomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protection from non-homologous end joining at telomere	ISO Inferred from Sequence Orthology more info
involved_in telomere capping	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere maintenance via telomere lengthening	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in telomeric 3' overhang formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomeric loop formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: 5' exonuclease Apollo

Names: DNA cross-link repair 1B protein; DNA cross-link repair 1B, PSO2 homolog; SNM1 homolog B; beta-lactamase MBLAC2

NP_001020483.1

EC 3.5.2.6

NP_598626.2

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025312.1 → NP_001020483.1 5' exonuclease Apollo isoform b

See identical proteins and their annotated locations for NP_001020483.1

Status: VALIDATED

Source sequence(s)

BC067017, BQ559794, CA317555

Consensus CDS

CCDS17695.1

UniProtKB/Swiss-Prot

Q8C7W7

Related

ENSMUSP00000067695.7, ENSMUST00000063502.13

Conserved Domains (3) summary

cd11662
Location:366 → 398

apollo_TRF2_binding; TRF2-binding region of apollo and similar proteins

pfam07522
Location:90 → 172

DRMBL; DNA repair metallo-beta-lactamase

cl23716
Location:1 → 25

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
NM_133865.2 → NP_598626.2 5' exonuclease Apollo isoform a

See identical proteins and their annotated locations for NP_598626.2

Status: VALIDATED

Source sequence(s)

AK049115, AK084347, BC067017, CA548899

Consensus CDS

CCDS17694.1

UniProtKB/Swiss-Prot

A0JLW2, B0V3N9, B0V3P0, Q3U4P2, Q3UUC7, Q3UV92, Q6NXL4, Q8BN95, Q8BQS8, Q8C7W7, Q921S0

Related

ENSMUSP00000029435.9, ENSMUST00000029435.15

Conserved Domains (3) summary

cd11662
Location:492 → 524

apollo_TRF2_binding; TRF2-binding region of apollo and similar proteins

pfam07522
Location:216 → 298

DRMBL; DNA repair metallo-beta-lactamase

cd16273
Location:6 → 151

SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain